Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen.
Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen.
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DOI：
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发表时间：
2002-11
影响因子：
2
通讯作者：
G. Mahady;S. Pendland;Gina S. Yun;Z. Z. Lu-Z.
中科院分区：
文献类型：
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作者：
G. Mahady;S. Pendland;Gina S. Yun;Z. Z. Lu-Z.
姜黄素是一种来源于姜黄（Curcuma longa）的多酚类化学成分，已显示可预防啮齿动物的胃癌和结肠癌。尽管姜黄素对幽门螺杆菌生长的影响还没有报道，但已经提出了许多化学预防作用的机制。H.幽门螺杆菌是第1类致癌物，与胃癌和结肠癌的发生有关。材料与方法采用姜黄甲醇提取物和姜黄素对19株H。pylori，包括5株cagA+菌株。结果姜黄醇提物和姜黄素对所有H. pylori的最小抑制浓度范围为6.25-50微克/毫升。结论姜黄素对H. pylori cagA ~+菌株，这可能是姜黄素发挥其化学预防作用的机制之一。
BACKGROUND Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. MATERIALS AND METHODS A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori, including 5 cagA+ strains. RESULTS Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. CONCLUSION These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.