Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep
Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep
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DOI：
10.1038/s41598-020-58612-4
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发表时间：
2020-02-03
影响因子：
4.6
通讯作者：
Struck, Aaron F.
中科院分区：
文献类型：
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作者：
Kang, Xuan;Boly, Melanie;Struck, Aaron F.
在这项研究中，我们应用高密度脑电记录（HD-EEG），定量表征发作间期癫痫样放电（IEDs）在不同睡眠阶段的细粒度时空分布。我们量化的空间范围和持续时间的差异，在头皮和皮质水平的IED使用HD-EEG源定位，在非快速眼动（NREM）睡眠和快速眼动（REM）睡眠，在6个药物难治性局灶性癫痫患者在癫痫监测单元入院。在单个受试者水平和不同睡眠阶段的组水平上对IED的持续时间和分布进行统计分析。对所有通道和时间点的多重比较进行了校正。与非快速眼动睡眠相比，快速眼动睡眠期间的简易爆炸装置的持续时间显着更短，空间更受限制。与NREM睡眠相比，REM睡眠中IEDs的位置与头皮EEG记录的电图发作区也显示出更高的一致性。本研究支持REM IED相对于NREM IED的定位价值，并表明HDEEG可能在癫痫手术检查中具有临床实用性。
In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration of IEDs at the scalp and cortical levels using HD-EEG source-localization, during non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monitoring unit admission. Statistical analyses were performed at single subject level and group level across different sleep stages for duration and distribution of IEDs. Tests were corrected for multiple comparisons across all channels and time points. Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spatially more restricted. Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrographic ictal onset zone from scalp EEG recording. This study supports the localizing value of REM IEDs over NREM IEDs and suggests that HDEEG may be of clinical utility in epilepsy surgery work-up.