Successive duplication-divergence mechanisms at the RCO locus contributed to leaf shape diversity in the Brassicaceae
Successive duplication-divergence mechanisms at the RCO locus contributed to leaf shape diversity in the Brassicaceae
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DOI：
10.1242/dev.164301
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发表时间：
2018-04
期刊：
影响因子：
4.6
通讯作者：
Susanna Streubel;M. A. Fritz;Melanie Teltow;C. Kappel;A. Sicard
中科院分区：
文献类型：
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作者：
Susanna Streubel;M. A. Fritz;Melanie Teltow;C. Kappel;A. Sicard
摘要基因复制是生物复杂性增加的主要驱动力。新复制的并列动物的分化可能允许新的功能进化，同时保持祖先的功能。或者，将祖先的功能划分给Paralog，可能会允许该角色的部分遵循独立的进化轨迹。我们研究了降低复杂性(RCO)基因座，它包含三个平行基因，它们是通过两个独立的基因复制事件进化的，它是十字花科植物叶形状进化的重复事件的基础。特别是，我们利用Capsella中三个潜在的功能对偶的存在来研究它们之间的功能分歧的程度。我们证明了RCO拷贝控制着叶片不同区域的生长。因此，在不同的十字花科谱系中保持活跃的拷贝有助于定义叶解剖模式。我们的结果进一步说明了连续的基因复制事件和随后的功能分化如何通过为特定功能提供独立的进化轨迹来增加性状的进化性，这些功能对给定的性状具有加性效应。摘要：在RCO Paralog中顺式调控的多样化导致了一个三基因簇的进化，其中每个成员调控不同方面的叶缘模式。
ABSTRACT Gene duplication is a major driver for the increase of biological complexity. The divergence of newly duplicated paralogs may allow novel functions to evolve, while maintaining the ancestral one. Alternatively, partitioning the ancestral function among paralogs may allow parts of that role to follow independent evolutionary trajectories. We studied the REDUCED COMPLEXITY (RCO) locus, which contains three paralogs that have evolved through two independent events of gene duplication, and which underlies repeated events of leaf shape evolution within the Brassicaceae. In particular, we took advantage of the presence of three potentially functional paralogs in Capsella to investigate the extent of functional divergence among them. We demonstrate that the RCO copies control growth in different areas of the leaf. Consequently, the copies that are retained active in the different Brassicaceae lineages contribute to define the leaf dissection pattern. Our results further illustrate how successive gene duplication events and subsequent functional divergence can increase trait evolvability by providing independent evolutionary trajectories to specialized functions that have an additive effect on a given trait. Summary: Cis-regulatory diversification among RCO paralogs has resulted in the evolution of a three-gene cluster, in which each member regulates distinct aspects of leaf margin patterning.