Effects of thirty elements on bone metabolism
Effects of thirty elements on bone metabolism
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DOI：
10.1016/j.jtemb.2015.06.005
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Goyens, Philippe
中科院分区：
文献类型：
--
作者：
Dermience, Michael;Lognay, Georges;Goyens, Philippe
人体骨骼由206块骨头组成，起着支撑身体、保护器官、促进运动和储存矿物质等重要作用。骨骼是由有机结构构成的，与骨细胞产生的无机基质紧密相连。许多元素在我们的环境中无处不在，其中许多元素影响骨骼代谢。根据浓度不同，大多数元素具有拮抗作用。的确，有些元素是必不可少的，有些则是有害的，而许多元素可能两者兼而有之。几种途径介导元素缺乏或过量对骨代谢的影响。本文旨在确定影响骨骼健康的所有因素，并探索它们的作用机制。迄今为止，这是第一次总结了30种矿物质对骨代谢的影响。(C) 2015 Elsevier GmbH版权所有。
The human skeleton, made of 206 bones, plays vital roles including supporting the body, protecting organs, enabling movement, and storing minerals. Bones are made of organic structures, intimately connected with an inorganic matrix produced by bone cells. Many elements are ubiquitous in our environment, and many impact bone metabolism. Most elements have antagonistic actions depending on concentration. Indeed, some elements are essential, others are deleterious, and many can be both. Several pathways mediate effects of element deficiencies or excesses on bone metabolism. This paper aims to identify all elements that impact bone health and explore the mechanisms by which they act. To date, this is the first time that the effects of thirty minerals on bone metabolism have been summarized. (C) 2015 Elsevier GmbH. All rights reserved.