Mouse Models in Meningioma Research: A Systematic Review.
Mouse Models in Meningioma Research: A Systematic Review.
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DOI：
10.3390/cancers13153712
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发表时间：
2021-07-26
期刊：
影响因子：
5.2
通讯作者：
Kalamarides M
中科院分区：
文献类型：
--
作者：
Boetto J;Peyre M;Kalamarides M
脑膜瘤是成人最常见的原始中枢神经肿瘤。癌症的小鼠模型用于研究疾病机制和建立临床前药物测试。在这篇综述中，我们描述了文献中报道的所有脑膜瘤小鼠模型。这包括将人脑膜瘤细胞注射到裸鼠中的移植模型和基因工程小鼠模型。总之，这些模型提供了研究肿瘤发生的起始和进展机制的可能性，并为大量创新药物和治疗方案的临床前测试提供了有用的工具。这篇综述提供了一个系统和全面的概述，这些不同的模型可以根据科学问题来回答。脑膜瘤是成人中最常见的原始中枢神经系统肿瘤。癌症的小鼠模型在理解疾病机制和建立临床前药物测试方面发挥了重要作用。随着时间的推移，各种脑膜瘤小鼠模型已经开发出来，随着我们对脑膜瘤生物学的理解和基因工程技术的改进而不断发展。我们回顾了文献中描述的所有脑膜瘤小鼠模型，包括人细胞系或患者来源肿瘤的异种移植模型（原位或异位）和基因工程小鼠模型（GEMM）。异种移植模型为大量创新药物和治疗方案的临床前测试提供了有用的工具，本文对其进行了总结。GEMM提供了在组织学、解剖学和遗传学水平上模仿人类脑膜瘤的可能性，并且在使肿瘤发生机制（包括开始和进展）得以解剖方面具有非常宝贵的价值。目前，研究人员有一系列不同的小鼠模型，可以根据要回答的科学问题来使用。
Meningiomas are the most frequent primitive central nervous tumors in adults. Mouse models of cancer are used to study disease mechanisms and to establish preclinical drug testing. In this review, we describe all mouse models of meningiomas reported in the literature. This includes graft models wherein human meningioma cells are injected in nude mice, and genetically engineered mouse models. Taken together, these models have offered the possibility to study tumorigenesis mechanisms of initiation and progression and have provided useful tools for preclinical testing of a huge range of innovative drugs and therapeutic options. This review provides a systematic and comprehensive overview on how these different models can be used depending on the scientific questions to be answered. Meningiomas are the most frequent primitive central nervous system tumors found in adults. Mouse models of cancer have been instrumental in understanding disease mechanisms and establishing preclinical drug testing. Various mouse models of meningioma have been developed over time, evolving in light of new discoveries in our comprehension of meningioma biology and with improvements in genetic engineering techniques. We reviewed all mouse models of meningioma described in the literature, including xenograft models (orthotopic or heterotopic) with human cell lines or patient derived tumors, and genetically engineered mouse models (GEMMs). Xenograft models provided useful tools for preclinical testing of a huge range of innovative drugs and therapeutic options, which are summarized in this review. GEMMs offer the possibility of mimicking human meningiomas at the histological, anatomical, and genetic level and have been invaluable in enabling tumorigenesis mechanisms, including initiation and progression, to be dissected. Currently, researchers have a range of different mouse models that can be used depending on the scientific question to be answered.
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