Aggressive Behavior Among Persons With Schizophrenia and Those Who Are Developing Schizophrenia: Attempting to Understand the Limited Evidence on Causality
Aggressive Behavior Among Persons With Schizophrenia and Those Who Are Developing Schizophrenia: Attempting to Understand the Limited Evidence on Causality
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DOI：
10.1093/schbul/sbx079
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发表时间：
2017-09-01
影响因子：
6.6
通讯作者：
Hodgins, Sheilagh
中科院分区：
文献类型：
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作者：
Hodgins, Sheilagh
精神分裂症患者和正在发展中的患者发生攻击行为（AGB）的风险增加。一些事件导致刑事起诉。大多数有犯罪行为的精神分裂症患者在第一次发作之前就有犯罪行为和/或AGB。这些个体中很大一部分有童年行为障碍（CD）和大脑异常的历史，提示神经发育异常，与其他精神分裂症患者不同。在乳糜泻之前导致精神分裂症的因素包括在儿童早期没有学会不要表现出攻击性，在面对他人时理解情绪的障碍，虐待以及随后的再次受害。其他没有反社会行为史的人在阳性症状增加和疾病发作时开始参与AGB。他们成为受害者的风险也很高。与逆境结合的压力调节相关的特定遗传变异与AGB和精神病症状相关。有效治疗行为问题和防止受害将减少精神分裂症患者的AGB。
People with, and those who are developing, schizophrenia are at increased risk to engage in aggressive behavior (AGB). Some incidents lead to criminal prosecution. Most people with schizophrenia who commit crimes engage in delinquency and/or AGB prior to first episode. A large proportion of these individuals have a history of childhood conduct disorder (CD) and brain abnormalities suggestive of abnormal neural development distinctive from that of others with schizophrenia. Factors contributing to schizophrenia that is preceded by CD include failing to learn not-to-behave aggressively in early childhood, impairments in understanding emotions in the faces of others, maltreatment, and subsequent re-victimization. Others with no history of antisocial behavior begin engaging in AGB as positive symptoms increase and illness onsets. They too are at elevated risk to be victimized. Specific genetic variants linked to stress regulation in combination with adversity have been associated both with AGB and psychotic symptoms. Effectively treating conduct problems and preventing victimization would reduce AGB by persons with schizophrenia.