Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT
Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT
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DOI：
10.1148/radiol.10100322
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发表时间：
2010-12-01
期刊：
影响因子：
19.7
通讯作者：
De Backer, Wilfried
中科院分区：
文献类型：
--
作者：
De Backer, Jan W.;Vos, Wim G.;De Backer, Wilfried
目的：为了比较使用数值流模拟的结果，结合单光子发射型计算机断层扫描（SPECT）和计算机断层扫描（CT）的结果，并证明正确的边界条件的数值方法，以解释大量的患者间的变异性在气道geometrical.Materials和方法的重要性：这项研究是由所有相关机构的审查委员会批准。所有患者均签署了知情同意书。在这项研究中，6名轻度哮喘患者（3名男性; 3名女性;总体平均年龄，46岁± 17岁[标准差]）接受了功能残气量和总肺容量的CT以及SPECT/CT。CT数据用于分割和计算流体动力学（CFD）模拟。对气流分布进行了比较，（a）通过示踪剂浓度分析的SPECT/CT，（B）通过肺叶扩张测量的CT，以及（c）通过流动计算机模拟的CFD。结果：SPECT/CT、CT和CFD在气流分布和热点检测方面具有良好的一致性。CFD和CT与SPECT/CT的内部气流分布的平均差异小于3%。Heterodynamics的通气模式可以检测到SPECT/CT和CFD.Conclusion：本研究的结果表明，患者特定的计算机模拟与适当的边界条件产生的信息，是类似的功能成像工具，如SPECT/CT。(C)RSNA，2010年
Purpose: To compare the results obtained by using numerical flow simulations with the results of combined single photon emission computed tomography (SPECT) and computed tomography (CT) and to demonstrate the importance of correct boundary conditions for the numerical methods to account for the large amount of interpatient variability in airway geometry.Materials and Methods: This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years +/- 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined.Results: Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD.Conclusion: This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT. (C) RSNA, 2010