High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate
复制标题
DOI：
10.1016/j.molmet.2012.11.001
复制
发表时间：
2013-02-01
影响因子：
8.1
通讯作者：
Grove, Kevin L.
中科院分区：
文献类型：
--
作者：
Comstock, Sarah M.;Pound, Lynley D.;Grove, Kevin L.
我们调查了不良的母体营养和代谢健康对非人灵长类(NHP)胰岛发育的影响。有趣的是，高脂饮食(HFD)喂养的动物的胎儿后代具有正常的总胰岛和β细胞质量；然而，α细胞质量显著减少，参与α细胞分化的转录因子表达减少。在幼年动物中，断奶后所有饲养在HFD上的后代都表现出胰岛总质量的增加，而对照后代的胰岛数量增加，HFD后代的胰岛尺寸增加。最后，当对照后代的α和β细胞增加时，HFD后代只增加了β细胞的数量。这些研究表明，在NHP怀孕期间食用HFD饮食，与母亲的代谢健康无关，会导致阿尔法细胞可塑性的长期异常，这可能导致慢性病易感性。(C)2012年爱思唯尔股份有限公司。
We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and beta cell mass; however, there was a significant reduction in alpha cell mass, and decreased expression of transcription factors involved in alpha cell differentiation. In juvenile animals all offspring maintained on a HFD during the postweaning period demonstrated increases in total islet mass, however, the control offspring displaying increased islet number, and HFD offspring displayed increased islet size. Finally, while control offspring had increases in alpha and beta cells, the HFD offspring had increases only in beta cell number. These studies indicate that consumption of a HFD diet during pregnancy in the NHP, independent of maternal metabolic health, causes long-term abnormalities in alpha cell plasticity that may contribute to chronic disease susceptibility. (C) 2012 Elsevier GmbH.