New experimental model of meningeal leukemia.
New experimental model of meningeal leukemia.
复制标题
脑膜白血病新实验模型。
作者：
R. Peterson;J. Varakis;L. Cheshire
脑膜白血病是白血病常见的致命并发症。设计更好的预防或治疗方案的努力受到有关该过程发病机制的知识的巨大差距的限制。本报告描述了一种新的脑膜白血病实验模型，它应该促进其研究并填补一些空白。t细胞淋巴瘤最初在C3H小鼠中由格罗斯小鼠白血病病毒诱导，在同基因小鼠中作为可移植的肿瘤系建立。当将三种肿瘤系静脉注射到正常受体动物体内时，会产生脑膜白血病。其他的主要是内脏淋巴瘤。
Meningeal leukemia is a common, often fatal complication of leukemia. Efforts to devise better prophylactic or therapeutic regimens have been limited by large gaps in knowledge regarding the pathogenesis of the process. This report describes a new experimental model of meningeal leukemia that should facilitate its study and fill some of the gaps. T-cell lymphomas, originally induced in C3H mice by Gross murine leukemia virus, were established as transplantable tumor lines in syngeneic mice. Three of ten tumor lines produced meningeal leukemia when injected i.v. into normal recipient animals. The others produced predominantly visceral lymphomas.