Counterfeit and substandard antimalarial drugs in Cambodia
Counterfeit and substandard antimalarial drugs in Cambodia
复制标题
DOI：
10.1016/j.trstmh.2006.01.003
复制
发表时间：
2006-11-01
影响因子：
2.2
通讯作者：
Smine, A.
中科院分区：
文献类型：
--
作者：
Lon, C. T.;Tsuyuoka, R.;Smine, A.
假冒伪劣抗疟药物可能导致死亡，并导致疟疾抗药性问题日益严重，特别是在东南亚。自2003年以来，柬埔寨在哨点定期监测公共和私营卫生部门的抗疟药物质量。我们调查了四个省所有498个已知设施和药品销售点中的34%。我们收集了451个药物样本;其中79%没有在柬埔寨药物和食品部（DDF）注册。百分之二十七的样品未能通过薄层色谱和崩解试验;所有这些都是未注册的产品。国家疟疾控制方案和DDF立即采取行动打击假药。他们通过警告信、手册、年度疟疾会议和其他培训活动，与省卫生厅就存在假冒抗疟药物进行沟通。开展了电视宣传运动，提醒民众警惕假药。此外，国家疟疾防治方案一直在公共和私营部门推广使用青蒿琥酯和甲氟喹泡罩联合包装的高质量抗疟药物。有关政府机构和利益攸关方需要制定和执行适当的战略，以加强该国的药品质量保证和管制系统。(C)2006年皇家热带医学和卫生学会。由Elsevier Ltd.出版。r保留所有权利。
Counterfeit and substandard antimalarial drugs can cause death and contribute to the growing malaria drug resistance problem, particularly in Southeast Asia. Since 2003 in Cambodia the quality of antimalarial drugs both in the public and private health sector is regularly monitored in sentinel sites. We surveyed 34% of all 498 known facilities and drug outlets in four provinces. We collected 451 drug samples; 79% of these were not registered at the Cambodia Department of Drugs and Food (DDF). Twenty-seven percent of the samples failed the thin layer chromatography and disintegration tests; all of them were unregistered products. Immediate action against counterfeit drugs was taken by the National Malaria Control Program (NMCP) and the DDF. They communicated with the Provincial Health Department about the presence of counterfeit antimalarial drugs through alert letters, a manual, annual malaria conferencing and other training occasions. Television campaigns to alert the population about counterfeit drugs were conducted. Moreover, the NMCP has been promoting the use of good quality antimalarial drugs of a blister co-packaged combination of artesunate and mefloquine in public and private sectors. Appropriate strategies need to be developed and implemented by relevant government agencies and stakeholders to strengthen drug quality assurance and control systems in the country. (C) 2006 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd.r All rights reserved.