ROUTE OF ENTRY OF LEPTOSPIRES INTO KIDNEY TUBULE
ROUTE OF ENTRY OF LEPTOSPIRES INTO KIDNEY TUBULE
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DOI：
10.1099/00222615-9-2-149
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发表时间：
1976-01-01
影响因子：
3
通讯作者：
MARSHALL, RB
中科院分区：
文献类型：
--
作者：
MARSHALL, RB
为了研究问号钩端螺旋体波莫纳血清型通过肾脏的迁移，对传统饲养的 2 或 3 周龄小鼠进行腹膜内感染。与这个有机体。在最初的 4 天内，微生物从毛细血管腔迁移到间质组织并引起间质水肿。到第 10 天，它们出现在近曲小管的上皮细胞之间，到第 14 天，许多细胞位于管腔内。没有证据表明近端小管细胞内存在存活的钩端螺旋体，尽管偶尔观察到溶酶体内类似钩端螺旋体碎片的结构。在研究期间没有发现肾小球病变。
To study the migration of Leptospira interrogans serotype pomona through the kidney, conventionally-reared mice aged 2 or 3 wk were infected i.p. with this organism. Within the first 4 days the organisms migrated from the capillary lumina to the interstitial tissue and provoked interstitial edema. By the 10th day they were seen between the epithelial cells of the proximal convoluted tubules and by the 14th day many were located within tubular lumina. There was no evidence of viable leptospires within the cells of the proximal tubules, though occasionally structures resembling leptospiral fragments inside lysosomes were observed. At no stage during the study were glomerular lesions seen.