Arithmetic ability and parietal alterations: A diffusion tensor imaging study in Velocardiofacial syndrome
Arithmetic ability and parietal alterations: A diffusion tensor imaging study in Velocardiofacial syndrome
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DOI：
10.1016/j.cogbrainres.2005.09.013
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Reiss, AL
中科院分区：
文献类型：
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作者：
Barnea-Goraly, N;Eliez, S;Reiss, AL
腭心面综合征 (VCFS) 是一种先天性异常，会导致躯体以及认知和精神障碍。先前的研究发现 VCFS 受试者的算术能力存在特定缺陷。在这项研究中，我们研究了白质通路异常是否与算术能力下降相关。 19 名 7-19 岁的 VCFS 患者接受了弥散加权磁共振成像 (MPI) 扫描。在对任何智商和年龄相关效应进行共变后，使用线性回归模型将分数各向异性 (FA) 值与 WISC/WAIS 上算术子量表的分数逐个体素地关联起来。 WISC/WAIS 算术评分与左侧边缘上回、角回附近以及左侧顶内沟附近的白质束 FA 值之间存在统计学上显着的正相关性。顶叶下叶白质结构畸变可能导致 VCFS 算术能力下降。 (c) 2005 Elsevier B.V. 保留所有权利。
Velocardiofacial syndrome (VCFS) is a congenital anomaly that causes somatic as well as cognitive and psychiatric impairments. Previous studies have found specific deficits in arithmetic abilities in subjects with VCFS. In this study, we investigated whether abnormalities in white matter pathways are correlated with reduced arithmetic ability. Nineteen individuals with VCFS aged 7-19 years received diffusion-weighted magnetic resonance imaging (MPI) scans. A linear regression model was used to correlate fractional anisotropy (FA) values with scores of the arithmetic subscale on the WISC/WAIS on a voxel-by-voxel basis, after covarying for any IQ- and age-related effects. There was a statistically significant positive correlation between the arithmetic score on the WISC/WAIS and FA values in white matter tracts adjacent to the left supramarginal and angular gyri, as well as along the left intraparietal sulcus. Inferior parietal lobe white matter Structural aberrations may contribute to reduced arithmetic ability in VCFS. (c) 2005 Elsevier B.V. All rights reserved.