Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa
Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa
复制标题
DOI：
10.1016/j.dci.2013.03.008
复制
发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Vervelde, Lonneke
中科院分区：
文献类型：
--
作者：
de Geus, Eveline D.;Vervelde, Lonneke
巨噬细胞（MPh）和树突状细胞（DC）是单核吞噬细胞系统的成员。在鸡中，缺乏区分MPh和DC的标记物，但MPh和DC是否可以在人类和小鼠中区分仍存在争议，尽管有许多标记物可用。本文就鸡DC和MPh的功能、MPh和DC表达的与病原体识别有关的受体以及DC和MPh对呼吸道和肠道病原体的反应等方面的研究进展作一综述。此外，描述了调节MPh和DC应答以增强抗病性的潜在机会，突出了通过营养品和疫苗接种的调节。(C)2013爱思唯尔有限公司保留所有权利。
Macrophages (MPh) and dendritic cells (DC) are members of the mononuclear phagocyte system. In chickens, markers to distinguish MPh from DC are lacking, but whether MPh and DC can be distinguished in humans and mice is under debate, despite the availability of numerous markers. Mucosal MPh and DC are strategically located to ingest foreign antigens, suggesting they can rapidly respond to invading pathogens.This review addresses our current understanding of DC and MPh function, the receptors expressed by MPh and DC involved in pathogen recognition, and the responses of DC and MPh against respiratory and intestinal pathogens in the chicken. Furthermore, potential opportunities are described to modulate MPh and DC responses to enhance disease resistance, highlighting modulation through nutraceuticals and vaccination. (C) 2013 Elsevier Ltd. All rights reserved.