Interventions to increase racial and ethnic minority accrual into cancer clinical trials: A systematic review.
Interventions to increase racial and ethnic minority accrual into cancer clinical trials: A systematic review.
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作者：
尽管1993年美国国立卫生研究院的《振兴法案》规定妇女和代表性不足的少数群体在临床试验中的代表性，但种族和族裔少数群体在临床试验中的代表性仍然不足。虽然黑人占癌症人口的15%，西班牙裔占13%，但他们的临床试验入组率不成比例地低，分别为4%至6%和3%至6%。进行了一项系统性综述，探讨旨在改善REM癌症临床试验（CCT）入组的干预措施。自1993年以来，对PubMed、科克伦中心和奥维德PsycINFO进行了英语研究的系统检索。入选标准包括同行评审的美国研究，其干预措施旨在招募代表性不足的少数成年患者参加癌症临床试验。REM群体被定义为黑人、西班牙裔、亚洲人、美洲印第安人和夏威夷土著/其他太平洋岛民。系统检索识别了3123项研究，其中9项符合纳入标准。干预措施包括患者导航/指导（n = 4），临床试验教育视频（n = 2），机构研究基础设施的变化（n = 1），建立关系和社会营销招聘模型（n = 1），以及提供者的文化能力培训（n = 1）。在三个患者导航干预、一个临床试验教育视频和一个机构研究基础设施变更中显示了统计学显著的增加。本系统综述阐明了在各种临床环境中增加REM背景患者CCT招募的几种潜在机制，需要进一步探索更多的随机对照试验。这些干预措施对REM的好处。
Racial and ethnic minorities (REMs) continue to be underrepresented in clinical trials despite the 1993 National Institutes of Health’s Revitalization Act mandating the representation of women and underrepresented minority groups in clinical trials. Although Blacks represent 15% and Hispanics 13% of the cancer population, their clinical trial enrollment rates are disproportionately low at 4% to 6% and 3% to 6%, respectively. A systematic review exploring interventions aimed at improving cancer clinical trial (CCT) enrollment for REMs was conducted. A systematic search of PubMed, Cochrane CENTRAL, and Ovid PsycINFO was conducted for English-language studies since 1993. Inclusion criteria included peer-reviewed, US-based studies with interventions aimed to recruit underrepresented minority adult patients into cancer clinical trials. REM groups were defined as Black, Hispanic, Asian, American Indian, and Native Hawaiian/other Pacific Islander. The systematic search identified 3123 studies, of which nine met inclusion criteria. Interventions included patient navigation/coaching (n = 4), a clinical trial educational video (n = 2), institutional research infrastructure changes (n = 1), a relationship building and social marketing recruitment model (n = 1), and cultural competency training for providers (n = 1). A statistically significant improvement in accrual was shown in three of the patient navigation interventions, one of the clinical trial educational videos and an institutional research infrastructure change. This systematic review illustrates several potential mechanisms by which to increase CCT recruitment for patients of REM backgrounds in various clinical settings More randomized controlled trials are needed to further explore. the benefits of these interventions for REMs.
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影响因子：
--
作者：
Brown RF;Cadet DL;Houlihan RH;Thomson MD;Pratt EC;Sullivan A;Siminoff LA
通讯作者：
Siminoff LA
影响因子：
1.5
作者：
Cook ED;Yeager KA;Cecchini RS;Boparai J;Brown CL;Duncan M;Cronin WM;Paskett ED
通讯作者：
Paskett ED
影响因子：
6.2
作者：
Guadagnolo, B. Ashleigh;Boylan, Amy;Sargent, Michele;Koop, David;Brunette, Deb;Kanekar, Shalini;Shortbull, Vanessa;Molloy, Kevin;Petereit, Daniel G.
通讯作者：
Petereit, Daniel G.
影响因子：
2.3
作者：
Anwuri, Victoria V.;Hall, Lannis E.;Colditz, Graham A.
通讯作者：
Colditz, Graham A.
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N