Anxious/Depressed Symptoms are Linked to Right Ventromedial Prefrontal Cortical Thickness Maturation in Healthy Children and Young Adults
Anxious/Depressed Symptoms are Linked to Right Ventromedial Prefrontal Cortical Thickness Maturation in Healthy Children and Young Adults
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DOI：
10.1093/cercor/bht151
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发表时间：
2014-11-01
期刊：
影响因子：
3.7
通讯作者：
Karama, Sherif
中科院分区：
文献类型：
--
作者：
Ducharme, Simon;Albaugh, Matthew D.;Karama, Sherif
焦虑/抑郁特质与神经成熟之间的关系在很大程度上尚未研究。在健康的神经发育过程中描述这种关系对于理解与儿童/青少年发作的情绪/焦虑障碍的出现相关的过程至关重要。在这项研究中，混合效应模型被用来确定纵向皮质厚度相关的儿童行为检查表（CBCL）和年轻的成人自我报告焦虑/抑郁评分在健康儿童。分析纳入了341例年龄在4.9至22.3岁之间的受试者，这些受试者在最多3个时间点以2年的间隔（586次MRI扫描）进行了重复MRI检查。有一个显着的“CBCL的上升/抑郁的年龄”的相互作用，在右腹内侧前额叶皮层（vmPFC），包括内侧眶额，直回，和膝下前扣带区的皮质厚度。焦虑/抑郁评分在较年轻的年龄（< 9岁）与厚度呈负相关，但在较年长的年龄（15-22岁）与厚度呈正相关，极性的转变发生在12岁左右。这继发于评分较高的受试者中vmPFC皮质变薄速率较慢。在年轻人（18-22岁）中，Anglands/Depressed评分也与楔前叶/后扣带皮质厚度呈正相关。潜在的神经生物学机制，这种成熟模式的建议。这些结果表明，年龄的动态影响之间的关系VMPFC和发展中的大脑中的负面影响。
The relationship between anxious/depressed traits and neuromaturation remains largely unstudied. Characterizing this relationship during healthy neurodevelopment is critical to understanding processes associated with the emergence of child/adolescent onset mood/anxiety disorders. In this study, mixed-effects models were used to determine longitudinal cortical thickness correlates of Child Behavior Checklist (CBCL) and Young Adult Self Report Anxious/Depressed scores in healthy children. Analyses included 341 subjects from 4.9 to 22.3 year-old with repeated MRI at up to 3 time points, at 2-year intervals (586 MRI scans). There was a significant "CBCL Anxious/Depressed by Age" interaction on cortical thickness in the right ventromedial prefrontal cortex (vmPFC), including the medial orbito-frontal, gyrus rectus, and subgenual anterior cingulate areas. Anxious/Depressed scores were negatively associated with thickness at younger ages (< 9 years), but positively associated with thickness at older ages (15-22 years), with the shift in polarity occurring around age 12. This was secondary to a slower rate of vmPFC cortical thinning in subjects with higher scores. In young adults (18-22 years), Anxious/Depressed scores were also positively associated with precuneus/posterior cingulate cortical thickness. Potential neurobiological mechanisms underlying this maturation pattern are proposed. These results demonstrate the dynamic impact of age on relations between vmPFC and negative affect in the developing brain.