Anti-Ri-associated paraneoplastic cerebellar degeneration and breast cancer: An autopsy case study
Anti-Ri-associated paraneoplastic cerebellar degeneration and breast cancer: An autopsy case study
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DOI：
10.1016/j.clineuro.2008.06.016
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发表时间：
2008-12-01
影响因子：
1.9
通讯作者：
Garus, F.
中科院分区：
文献类型：
--
作者：
Brieva-Ruiz, L.;Diaz-Hurtado, M.;Garus, F.
几种抗神经元抗体与副肿瘤性小脑变性有关。在某些情况下，抗Ri是这些抗体之一，但它更常见于妇科肿瘤背景下的副肿瘤性眼阵挛肌阵挛。抗Ri自身抗体被认为是针对肿瘤神经抗原NOVA-1和NOVA-2的，其由肿瘤以及神经元表达。尽管积极的多模式免疫抑制治疗已被使用，但这两种综合征的治疗结果均令人失望。抗Ri副肿瘤性小脑变性的病例很少，没有进行过病理学研究。我们报告的病理学研究的病人谁死于抗Ri阳性副肿瘤小脑变性与乳腺癌仅在尸检证实。(C)2008 Elsevier B. V.保留所有权利。
Several antineuronal antibodies are associated with paraneoplastic cerebellar degeneration. Anti-Ri is one of these antibodies in some cases but it is more commonly associated with paraneoplastic opsoclonus myoclonus in the context of gynecological neoplasia. Anti-Ri autoantibodies are thought to be directed against onconeural antigens, NOVA-1 and NOVA-2, that are expressed by the tumor as well as by neurons. The results of the treatment of both syndromes have been disappointing, although aggressive multimodality immunosuppressive treatments have been used. There are few cases of anti-Ri paraneoplastic cerebellar degeneration and none has been pathologically studied. We report the pathological study of a patient who died from anti-Ri-positive paraneoplastic cerebellar degeneration associated with breast cancer only confirmed at autopsy. (C) 2008 Elsevier B.V. All rights reserved.