ARTERIAL-WALL THICKNESS IS ASSOCIATED WITH PREVALENT CARDIOVASCULAR-DISEASE IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
ARTERIAL-WALL THICKNESS IS ASSOCIATED WITH PREVALENT CARDIOVASCULAR-DISEASE IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1161/01.str.26.3.386
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发表时间：
1995-03-01
期刊：
影响因子：
8.3
通讯作者：
HEISS, G
中科院分区：
文献类型：
--
作者：
BURKE, GL;EVANS, GW;HEISS, G
背景和目的本研究旨在评估美国中年人心血管疾病流行与动脉壁厚度之间的关系。方法在社区动脉粥样硬化风险（ARIC）研究基线检查期间（1987 - 1989）评估13870名45 - 64岁的黑人和白人男性和女性，既往存在的冠心病、脑血管疾病和周围血管疾病与颈动脉和腘动脉内膜-内侧厚度（IMT）的关系（通过b超测量）。根据参与者的自我报告和基线检查的测量（包括心电图、空腹血糖和药物使用）确定流行疾病。结果在四个种族和性别阶层中，患有普遍临床心血管疾病的参与者的平均颈动脉远壁IMT始终高于无疾病的受试者。同样，在IMT逐渐变厚的参与者中，心血管疾病的患病率始终更高。在有症状的外周血管疾病中，颈动脉IMT与流行疾病相关的差异最大（4个种族-性别组的IMT高出0.09至0.22 mm）。结论：这些数据表明，在中年心血管疾病患者中，动脉壁厚度明显增大。颈动脉和腘动脉IMT均与影响远端血管床（如脑、外周和冠状动脉血管床）的临床表现的心血管疾病有关。
Background and Purpose This study was done to assess the relationship between prevalent cardiovascular disease and arterial wall thickness in middle-aged US adults.Methods The association of preexisting coronary heart disease, cerebrovascular disease, and peripheral vascular disease with carotid and popliteal intimal-medial thickness (IMT) (measured by B-mode ultrasound) was assessed in 13 870 black and white men and women, aged 45 to 64, during the Atherosclerosis Risk in Communities (ARIC) Study baseline examination (1987 through 1989). Prevalent disease was determined according to both participant self-report and measurements at the baseline examination (including electrocardiogram, fasting blood glucose, and medication use).Results Across four race and gender strata, mean carotid far wall IMT was consistently greater in participants with prevalent clinical cardiovascular disease than in disease-free subjects. Similarly, the prevalence of cardiovascular disease was consistently greater in participants with progressively thicker IMT. The greatest differences in carotid IMT associated with prevalent disease were observed for reported symptomatic peripheral vascular disease (0.09 to 0.22 mm greater IMT in the four race-gender groups).Conclusions These data document the substantially greater arterial wall thickness observed in middle-aged adults with prevalent cardiovascular disease. Both carotid and popliteal arterial IMT were related to clinically manifest cardiovascular disease affecting distant vascular beds, such as the cerebral, peripheral, and coronary artery vascular beds.