Obstetric outcome in women with endometriosis -: A matched case-control study
Obstetric outcome in women with endometriosis -: A matched case-control study
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DOI：
10.1159/000074815
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发表时间：
2003-01-01
影响因子：
2.1
通讯作者：
Heinonen, ST
中科院分区：
文献类型：
--
作者：
Kortelahti, M;Anttila, MA;Heinonen, ST
背景：免疫缺陷、血管生成活性改变、浸润性潜能和生长因子是子宫内膜异位症的可能因素。本研究的目的是确定子宫内膜异位症是否会影响妊娠的进程或结局。研究设计：在这项配对病例对照研究中，我们分析了1994年1月至2000年12月在库奥皮奥大学医院出生的137名子宫内膜异位症妇女和137名对照妇女的产科结局。在受影响的妇女中，诊断得到了组织学证实，而对照组只有在接受过与输卵管绝育有关的腹腔镜/子宫切除术，或与子宫内膜异位症无关的不孕症时，才有资格参加研究。结果：在子宫内膜异位症患者中，除平均母亲年龄(31.2岁，对照组为34岁)外，其他生殖危险因素均无统计学差异。足月分娩(137周)的平均出生体重(+/-SD)对照组为3,600(+/-542)g，研究组为3,547(+/-456)g。两组胎盘重量相似。与对照组相比，子宫内膜异位症患者的总体妊娠特征和妊娠结局指标相似。结论：子宫内膜异位症对产科结局的任何潜在负面影响都是无法检测到的。版权所有(C)2003 S.Karger AG，巴塞尔。
Background: Immunological deficiencies, altered angiogenic activity, infiltrative potential and growth factors are plausible factors behind endometriosis. The aim of this study was to determine whether endometriosis interferes with the course or outcome of pregnancy. Study Design: In this matched case-control study, we analyzed obstetric outcome among 137 women with endometriosis and 137 controls matched as regards IVF procedures and parity who gave singleton births at Kuopio University Hospital between January 1994 and December 2000. In affected women, the diagnosis was histologically verified, whereas the controls were eligible for the study only if they had undergone laparoscopy/tomy in connection with tubal sterilization, or infertility unrelated to endometriosis. Results: No statistically significant differences were detected in reproductive risk factors in women with endometriosis, with the exception of mean maternal age (31.2 years in the cases vs. 34 years in the controls). The mean birth weight (+/-SD) among those delivering at term ( 137 completed weeks) was 3,600 (+/-542) g in the control group and 3,547 (+/-456) g in the study group. Placental weight was comparable in both groups. Overall pregnancy characteristics and pregnancy outcome measures were similar in women affected by endometriosis when compared with the control group. Conclusions: Any potential negative effect of endometriosis on obstetric outcome was undetectable. Copyright (C) 2003 S. Karger AG, Basel.