Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling
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DOI：
10.1182/blood-2006-01-0143
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发表时间：
2006-07-01
期刊：
影响因子：
20.3
通讯作者：
von Boehmer, Harald
中科院分区：
文献类型：
--
作者：
Campese, Antonio F.;Garbe, Annette I.;von Boehmer, Harald
细胞内Notch的过表达在人类急性淋巴细胞性T细胞白血病（T- all）的发生中起重要作用。在小鼠模型中，研究表明notch依赖性T-ALL需要tcr前信号传导。在这里，我们表明tcr前信号是调节小鼠notch依赖性转化所必需的，但它不是维持T-ALL恶性生长所必需的。与之前的研究相反，我们发现疾病的发展不需要pre-TCR，但在Rag2（-/-）小鼠中，通过短暂模拟pre-TCR信号可以加速疾病的发展。
Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.