Aquaporins in the digestive system
Aquaporins in the digestive system
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DOI：
10.1007/s00795-004-0246-3
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发表时间：
2004-06
期刊：
影响因子：
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通讯作者：
T. Matsuzaki;Yuki Tajika;Abdushukur Ablimit;T. Aoki;H. Hagiwara;K. Takata
中科院分区：
文献类型：
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作者：
T. Matsuzaki;Yuki Tajika;Abdushukur Ablimit;T. Aoki;H. Hagiwara;K. Takata
液体的转移，如分泌和吸收，是消化系统的主要功能之一。水通道蛋白是一种水通道蛋白，提供跨细胞膜的水转移。消化系统中至少表达六种水通道蛋白亚型。水通道蛋白-1(Aquaporin-1，AQP1)广泛分布于小肠的毛细血管和小血管内皮细胞以及中枢乳管中。AQP1也存在于胰腺、肝脏和胆管的胆管系统中。AQP3主要表达于从口腔到胃的上消化道和从远端结肠到肛门的下消化道的上皮细胞。AQP4存在于胃的壁细胞和肠上皮细胞中。AQP5表达于唾液腺、幽门和十二指肠腺的腺泡细胞。AQP8表达于肠上皮、唾液腺、胰腺和肝脏。AQP9存在于肝脏和肠杯状细胞中。水通道蛋白在消化系统中有重要的作用，如AQP5在唾液分泌中的作用，对AQP5基因缺失的小鼠的研究表明。此外，水通过消化上皮的转移似乎不仅通过水通道蛋白发生，而且还通过其他转运体或通道系统发生。
Fluid transfer such as secretion and absorption is one of the major functions of the digestive system. Aquaporins are water channel proteins providing water transfer across the cellular membrane. At least six aquaporin isoforms are expressed in the digestive system. Aquaporin-1 (AQP1) is widely distributed in endothelial cells of capillaries and small vessels as well as in the central lacteals in the small intestine. AQP1 is also present in the duct system in the pancreas, liver, and bile duct. AQP3 is mainly expressed in the epithelia of the upper digestive tract from the oral cavity to the stomach and of the lower digestive tract from the distal colon to the anus. AQP4 is present in the parietal cells of the stomach and in the intestinal epithelia. AQP5 is expressed in acinar cells of the salivary, pyloric, and duodenal glands. AQP8 is expressed in the intestinal epithelia, salivary glands, pancreas, and liver. AQP9 is present in the liver and intestinal goblet cells. Aquaporins have important roles in the digestive system, such as AQP5 in saliva secretion, as shown by the studies on AQP5-null mice. In addition, water transfer across the digestive epithelia seems to occur not only via aquaporins but also via other transporter or channel systems.