Atypical chronic inflammatory demyelinating polyneuropathies
Atypical chronic inflammatory demyelinating polyneuropathies
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非典型慢性炎症性脱髓鞘性多发性神经病
DOI：
10.1136/jnnp-2018-319411
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Mori Masahiro
中科院分区：
文献类型：
--
作者：
Kuwabara Satoshi;Misawa Sonoko;Mori Masahiro
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种进行性超过2个月的免疫介导的神经病，包括几种临床亚型。1975年，Dyck等3描述了CIDP的经典原型，并强调了一个突出的临床特征是近端和远端肌肉的无力大约相等，这在其他神经长度依赖性多发性神经病中非常罕见。他们提出，这种非长度依赖性的模式是由神经根的病变引起的，可能同样影响长神经和短神经。从目前的观点来看，假设是部分正确的，在经典的CIDP，远端神经末梢和神经根，血神经屏障是解剖缺陷，主要受到影响，证明了电诊断和神经影像学的结果。[4]然而，1991年晚些时候，美国神经病学学会（AAN）提出的研究标准将临床纳入标准定义为“超过一个肢体的运动感觉功能障碍”。5根据AAN标准，任何获得性脱髓鞘神经病，例如主要是远端（远端获得性脱髓鞘对称性（DADS）），不对称/多灶性（Lewis-Sumner综合征）、纯运动神经病或纯感觉神经病或甚至多灶性运动神经病可以包括在CIDP中。欧洲神经学会联合会和周围神经学会联合工作组（EFNS/PNS）将CIDP合理地分为临床亚型; Dyck等3提出的经典CIDP被归类为“典型CIDP”，而“非典型CIDP”包括Lewis-Sumner综合征、DADS和其他变体。6然后几项研究报告了频率和特征。在他们的JNNP论文中，Donuddu及其同事7报道了一项意大利多中心数据库研究的结果，该研究共涉及460例CIDP患者。发生时
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy progressive for more than 2 months, including several clinical subtypes. 1 2 In 1975, Dyck et al 3 described the classical prototype of CIDP, and emphasised that a prominent clinical feature is weakness of the proximal and distal muscles about equally which is very rarely seen in other nerve length-dependent polyneuropathies. They proposed that such non-length-dependent pattern was caused by lesions in the nerve roots, presumably affecting the long and short nerves equally. From a current viewpoint, the assumption is partly correct; in classical CIDP, the distal nerve terminals and nerve roots, where the blood–nerve barrier is anatomically deficient, are predominantly affected, evidenced by electrodiagnostic and neuroimaging findings. 4 However, later in 1991 the research criteria proposed by the American Academy of Neurology (AAN) defined clinical inclusion criterion as ‘motor-sensory dysfunction of more than one limb’. 5 According to the AAN criteria, any acquired demyelinating neuropathies, such as predominantly distal (distal acquired demyelinating symmetric (DADS)), asymmetric/multifocal (Lewis-Sumner syndrome), pure motor, or pure sensory neuropathy or even multifocal motor neuropathy could be included in CIDP.In 2005, the Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society (EFNS/PNS) reasonably classified CIDP into clinical subtypes; the classical CIDP proposed by Dyck et al 3 was categorised as ‘typical CIDP’, and ‘atypical CIDP’included Lewis-Sumner syndrome, DADS and other variants. 6 Then several studies have reported the frequency and features. In their JNNP paper, Donuddu and colleagues 7 reported the results of an Italian multicentre database study involving a total of 460 patients with CIDP. At the time of
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影响因子：
11
作者：
Kuwabara, S;Ogawara, K;Hattori, T
通讯作者：
Hattori, T
影响因子：
11
作者：
Doppler, Kathrin;Stengel, Helena;Sommer, Claudia
通讯作者：
Sommer, Claudia
慢性炎症性脱髓鞘性多发性神经病（CIDP）诊断的研究标准
影响因子：
9.9
作者：
T. Kolatt;M. Bartelmann
通讯作者：
M. Bartelmann
慢性炎症性多发性神经根神经病。
影响因子：
8.9
作者：
P. Dyck;A. Lais;M. Ohta;J. A. Bastron;H. Okazaki;R. Groover
通讯作者：
R. Groover
欧洲神经学会联合会/周围神经学会指南*关于慢性炎症性脱髓鞘性多发性神经根神经病的治疗。
影响因子：
3.8
作者：
R. Hughes;P. Bouche;D. Cornblath;E. Evers;R. Hadden;A. Hahn;I. Illa;C. Koski;J. Léger;E. Nobile‐Orazio;J. Pollard;C. Sommer;P. Bergh;P. Doorn;I. N. Schaik
通讯作者：
I. N. Schaik