Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis.
Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis.
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DOI：
10.18632/oncotarget.12523
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发表时间：
2016-11-22
期刊：
影响因子：
--
通讯作者：
Zhu H
中科院分区：
文献类型：
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作者：
Bai B;Wang X;Chen E;Zhu H
人巨细胞病毒（HCMV）感染是近年来发现的肿瘤发生的重要因素之一。目前的研究使用荟萃分析技术来探讨肿瘤组织中HCMV的患病率以及人巨细胞病毒与结直肠癌（CRC）风险之间的关系。11项检测肿瘤组织中HCMV DNA的研究纳入荟萃分析。患病率和比值比（OR）是两个主要参数。肿瘤组织中人巨细胞病毒DNA的总体患病率为27.5%（95% CI = 17.2%-37.8%）。二元Logistic回归分析显示，2010年之前报道的涉及发达地区患者福尔马林固定标本的研究代表了较低的HCMV比例。肿瘤组织的病毒感染率显著高于正常组织（OR = 6.59，95%CI = 4.48 - 9.69，I2 = 0%，P = 0.71）。亚组分析显示，不同肿瘤分期、不同组织学分级的肿瘤细胞以及不同类型的标本（息肉和腺癌）中病毒的感染率无差异。目前的研究结果表明，病毒感染与结直肠癌风险增加之间存在统计学关联。
Human cytomegalovirus infection (HCMV) has been recently considered as a factor for tumorigenesis. The current study used meta-analytical techniques to explore the prevalence of HCMV in tumor tissues and the relationship between human cytomegalovirus and colorectal cancer (CRC) risk. 11 studies detecting HCMV DNA in tumor tissues were included in meta-analysis. The prevalence rate and odds ratio (OR) were two main parameters. The overall prevalence of human cytomegalovirus DNA in tumor tissues were 27.5% (95% CI = 17.2%−37.8%). Binary logistic regression showed that the studies reported before 2010 involving formalin-fixed specimens from patients in developed region represented a lower proportion of HCMV. The tumor tissues had a significantly higher rate of virus infection compared with normal tissues (OR = 6.59, 95% CI = 4.48−9.69, I2 = 0%, P = 0.71). Subgroup analysis revealed the prevalence of the virus didn't differ in patients with different tumor stages, in tumor cells with different histologic grades, also in different kinds of specimen (polyp and adenocarcinoma). The results of current study suggested a statistically association between the virus infection and an increased risk of colorectal cancer.