Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting
Spatio-temporal analysis of malaria vector density from baseline through intervention in a high transmission setting
复制标题
DOI：
10.1186/s13071-016-1917-3
复制
发表时间：
2016-12-12
影响因子：
3.2
通讯作者：
Tatem, Andrew J.
中科院分区：
文献类型：
--
作者：
Alegana, Victor A.;Kigozi, Simon P.;Tatem, Andrew J.
背景：自2000年以来，有效疟疾控制的增加有助于全球疟疾发病率和死亡率的下降。了解何时以及如何将现有干预措施结合起来以最大限度地发挥其对疟疾病媒的影响，可以为不同疟疾流行环境下的国家疟疾控制规划提供有价值的信息。在此，我们评估了乌干达东部疟疾高发地区室内滞留喷洒对疟疾病媒密度的影响，作为一项队列研究的一部分，该地区使用长效杀虫蚊帐（LLINs）的比例很高。方法：按月随机抽取107户按蚊，采用CDC灯诱法进行抽样。还通过问卷收集和记录了家庭中使用疟疾干预措施的情况。然后使用贝叶斯时空模型估计蚊子密度，调整气候和生态变量和干预措施。结果：冈比亚按蚊（sensu lato）数量最多（89.1%,n = 119,008）；狐猴（sensu lato） （10.1%, n = 13,529）。模拟结果表明，在氯菊酯浸渍杀虫剂覆盖率高（99%）的地区，室内残留喷洒（苯虫威）与蚊子媒介密度的大幅下降有关。对安的影响。Funestus （s.l。）（比率比0.1508;97.5% CI: 0.0144 ~ 0.8495）是An的2倍。冈比亚（1991年）（rr 0.5941; 97.5% ci: 0.1432-0.8577）。结论：在疟疾传播激烈的环境中，墙壁上有效成分的高覆盖率抑制了媒介种群。持续使用联合干预措施将对蚊子密度产生长期影响，限制传染性叮咬。
Background: An increase in effective malaria control since 2000 has contributed to a decline in global malaria morbidity and mortality. Knowing when and how existing interventions could be combined to maximise their impact on malaria vectors can provide valuable information for national malaria control programs in different malaria endemic settings. Here, we assess the effect of indoor residual spraying on malaria vector densities in a high malaria endemic setting in eastern Uganda as part of a cohort study where the use of long-lasting insecticidal nets (LLINs) was high.Methods: Anopheles mosquitoes were sampled monthly using CDC light traps in 107 households selected randomly. Information on the use of malaria interventions in households was also gathered and recorded via a questionnaire. A Bayesian spatio-temporal model was then used to estimate mosquito densities adjusting for climatic and ecological variables and interventions.Results: Anopheles gambiae (sensu lato) were most abundant (89.1%; n = 119,008) compared to An. funestus (sensu lato) (10.1%, n = 13,529). Modelling results suggest that the addition of indoor residual spraying (bendiocarb) in an area with high coverage of permethrin-impregnated LLINs (99%) was associated with a major decrease in mosquito vector densities. The impact on An. funestus (s. l.) (Rate Ratio 0.1508; 97.5% CI: 0.0144-0.8495) was twice as great as for An. gambiae (s. l.) (RR 0.5941; 97.5% CI: 0.1432-0.8577).Conclusions: High coverage of active ingredients on walls depressed vector populations in intense malaria transmission settings. Sustained use of combined interventions would have a long-term impact on mosquito densities, limiting infectious biting.