RENIN RESPONSE TO HEMORRHAGE AND HYPOTENSION IN THE AGLOMERULAR TOADFISH OPSANUS-TAU
RENIN RESPONSE TO HEMORRHAGE AND HYPOTENSION IN THE AGLOMERULAR TOADFISH OPSANUS-TAU
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DOI：
10.1152/ajpheart.1979.237.2.h105
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发表时间：
1979-01-01
影响因子：
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通讯作者：
ZUCKER, A
中科院分区：
文献类型：
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作者：
NISHIMURA, H;LUNDE, LG;ZUCKER, A
肾素和肾小球旁细胞在原始硬骨鱼类中进化而来，而致密斑细胞在脊椎动物系统发育中出现较晚。研究了具有肾素和颗粒细胞，但缺乏肾小球和致密斑的蟾蜍鱼是否存在肾小动脉压力感受器。在50%的海水中保存未麻醉的蟾蜍鱼，累计出血1.5、3、6、12和18 ml/kg，或单次大出血，导致平均主动脉压立即显著下降，血浆肾素活性（PRA）逐步升高（5-20倍）。罂粟碱（10 mg/kg）引起低血压和PRA升高。米诺地尔（6- 12mg /kg）既没有降低血压，也没有增加PRA。蟾鱼明显响应出血和急性低血压肾素释放，尽管没有黄斑致密。目前尚不清楚是否由于主动脉背压降低导致肾灌注压降低刺激了颗粒细胞中的受体，或者是否可能涉及肾神经。
Renal renin and the juxtaglomerular cells evolved in primitive bony fishes, whereas the macula densa emerged later in vertebrate phylogeny. Whether a renal arteriolar baroreceptor exists in the toadfish O. tau, which possess renin and granulated cells in the kidneys, but lack glomeruli and macula densa was studied. Cumulative hemorrhage of 1.5, 3, 6, 12 and 18 ml/kg, or a single massive bleeding from unanesthetized toadfish, kept in 50% seawater, caused an immediate and significant decrease in mean aortic pressure and stepwise increases (5-20 times) of plasma renin activity (PRA). Papaverine (10 mg/kg) caused hypotension and increased PRA. Minoxidil (6-12 mg/kg) neither decreased blood pressure nor increased PRA. Toadfish apparently respond to hemorrhage and acute hypotension with renin release despite the absence of a macula densa. It remains to be determined whether decreased renal perfusion pressure due to decreased dorsal aortic pressure stimulated the receptor in the granulated cells or whether the renal nerves may be involved.