NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline
NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline
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DOI：
10.1039/d1re00471a
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发表时间：
2022-01-06
影响因子：
3.9
通讯作者：
D'Agostino, Carmine
中科院分区：
文献类型：
--
作者：
Di Carmine, Graziano;Forster, Luke;D'Agostino, Carmine
将有机催化剂固定到固体载体上代表了一种非常有前途的解决方案，通过使其能够重复使用来解决其低生产率。在此，使用NMR弛豫测量，再加上反应筛选，被用来调查溶剂与固定化的催化剂基质的反应性上的不对称有机催化的羟醛缩合反应的相互作用的效果。为进一步发展这种复杂的，但有前途的催化体系提供了重要的见解。
Immobilisation of organocatalysts onto solid supports represents a very promising solution to tackle their low productivity by enabling their reuse. Herein, the use of NMR relaxation measurements, coupled with reaction screening, was used to investigate the effect of solvent interactions with the immobilised catalyst matrix on reactivity in an asymmetric organocatalysed aldol reaction. Important insights for the further development of such complex, yet promising catalytic systems are provided.