Adenosine receptors and inflammation.
Adenosine receptors and inflammation.
复制标题
DOI：
10.1007/978-3-540-89615-9_8
复制
发表时间：
2009-01-01
影响因子：
--
通讯作者：
Wilson, Constance N
中科院分区：
文献类型：
--
作者：
Blackburn, Michael R;Vance, Constance O;Wilson, Constance N
细胞外腺苷是在细胞攻击或组织损伤后以协调的方式从细胞中产生的。一旦产生，它通过与七个跨膜g蛋白偶联腺苷受体的相互作用作为自分泌和旁分泌信号分子。这些信号通路具有广泛的生理和病理生理功能。免疫细胞表达腺苷受体，并以多种方式对腺苷或腺苷激动剂作出反应。广泛的体外和体内研究已经确定了许多不同炎症细胞和各种炎症疾病过程中所有腺苷受体的有效抗炎功能。此外，特定的促炎功能也归因于腺苷受体的激活。腺苷信号在炎症调节中的强大作用表明，使用选择性激动剂和拮抗剂靶向特定腺苷受体激活或失活可能对许多疾病具有重要的治疗意义。本文综述了腺苷受体信号在各种炎症细胞和炎症模型中的现状，重点介绍了基于腺苷的治疗方法治疗炎症性疾病的进展。
Extracellular adenosine is produced in a coordinated manner from cells following cellular challenge or tissue injury. Once produced, it serves as an autocrine- and paracrine-signaling molecule through its interactions with seven-membrane-spanning G-protein-coupled adenosine receptors. These signaling pathways have widespread physiological and pathophysiological functions. Immune cells express adenosine receptors and respond to adenosine or adenosine agonists in diverse manners. Extensive in vitro and in vivo studies have identified potent anti-inflammatory functions for all of the adenosine receptors on many different inflammatory cells and in various inflammatory disease processes. In addition, specific proinflammatory functions have also been ascribed to adenosine receptor activation. The potent effects of adenosine signaling on the regulation of inflammation suggest that targeting specific adenosine receptor activation or inactivation using selective agonists and antagonists could have important therapeutic implications in numerous diseases. This review is designed to summarize the current status of adenosine receptor signaling in various inflammatory cells and in models of inflammation, with an emphasis on the advancement of adenosine-based therapeutics to treat inflammatory disorders.