Glucose hypermetabolism in the thalamus of patients with essential blepharospasm
Glucose hypermetabolism in the thalamus of patients with essential blepharospasm
复制标题
DOI：
10.1007/s00415-006-0468-5
复制
发表时间：
2007-07-01
影响因子：
6
通讯作者：
Ishii, Kenji
中科院分区：
文献类型：
--
作者：
Suzuki, Yukihisa;Mizoguchi, Shoichi;Ishii, Kenji
原发性眼睑痉挛 (EB) 被归类为局灶性肌张力障碍的一种形式，其特征是上面部肌肉组织的不自主痉挛。引起 EB 的基本神经过程尚不清楚。本研究的目的是调查 EB 患者的脑葡萄糖代谢情况，这些患者的症状通过注射肉毒杆菌毒素得到抑制。早期的研究被肌张力障碍症状本身产生的感觉反馈活动所混淆。通过使用 F-18-氟脱氧葡萄糖 (FDG) 的正电子发射断层扫描 (PET) 对 25 名 EB 患者（8 名男性和 17 名女性；年龄 52.6 +/- 10.1 岁）的脑葡萄糖代谢进行了检查。患者是清醒的，但通过注射肉毒杆菌毒素抑制了痉挛。 38 名正常志愿者（14 名男性和 24 名女性；年龄 58.2 +/- 7.3 岁）作为对照进行检查。通过统计参数映射（SPM99）检查两组之间的差异。在 EB 患者的丘脑和脑桥中检测到葡萄糖代谢显着增加。丘脑过度活跃可能是 EB 和其他类型局灶性肌张力障碍常见的关键病理生理变化。纹状体和小脑的活动可能依赖于感觉。
Essential blepharospasm (EB) is classified as a form of focal dystonia characterized by involuntary spasms of the musculature of the upper face. The basic neurological process causing EB is not known. The purpose of this study was to investigate cerebral glucose metabolism in patients with EB whose symptoms were suppressed by an injection of botulinum-A toxin. Earlier studies were confounded by sensory feedback activities derived from dystonic symptom itself. Cerebral glucose metabolism was examined by positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) in 25 patients (8 men and 17 women; age 52.6 +/- 10.1 years) with EB. The patients were awake but with the spasms suppressed by an injection of botulinum-A toxin. Thirty-eight normal volunteers (14 men and 24 women; age 58.2 +/- 7.3 years) were examined as controls. The difference between the two groups was examined by statistical parametric mapping (SPM99). A significant increase in the glucose metabolism was detected in the thalamus and pons in the EB patients. Hyperactivity in the thalamus may be a key pathophysiological change common to EB and other types of focal dystonia. The activity of the striatum and cerebellum are likely to be sensory dependent.