Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial
Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial
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DOI：
10.1093/ajcn/85.4.1023
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发表时间：
2007-04-01
影响因子：
7.1
通讯作者：
Roberts, Susan B.
中科院分区：
文献类型：
--
作者：
Das, Sai Krupa;Gilhooly, Cheryl H.;Roberts, Susan B.
背景资料：关于持续减肥的最佳饮食组成仍然没有达成共识。目的：目的是研究2种具有不同血糖负荷的饮食宏量营养素模式对坚持规定的热量限制（CR）方案、体重和脂肪减轻以及相关变量的影响。设计：在34名平均（+/- SD）年龄为35 +/-的健康超重成人中进行了一项随机对照试验（RCT），研究了高血糖负荷（HG）或低血糖负荷（LG）饮食（CR为30%）。6岁，体重指数（kg/m2）为27.6 +/- 1.4。所有食物均在控制混杂变量的饮食中提供6个月，受试者自我管理计划额外6个月。主要和次要结果包括双标记水测量的能量摄入，体重和脂肪，饥饿，饱腹感，和静息代谢率。结果：所有组在CR期间消耗的能量显著低于基线（P < 0.01），但能量摄入，体重，体脂和静息代谢率的变化组间无显着差异。两组摄入的能量均高于提供的能量（例如，HG和LG组3个月时CR分别为21%和28%，6个月时CR分别为16%和17%）。HG组和LG组12个月时的体重变化百分比分别为-8.04 +/- 4.1%和-7.81 +/- 5.0%。有没有影响的饮食组成的变化，饥饿，饱腹感，或满意度的数量和类型的食物在CR。结论：这些研究结果提供了更详细的证据表明，饮食差异很大的血糖负荷诱导可比的长期减肥。
Background: There remains no consensus about the optimal dietary composition for sustained weight loss.Objective: The objective was to examine the effects of 2 dietary macronutrient patterns with different glycemic loads on adherence to a prescribed regimen of calorie restriction (CR), weight and fat loss, and related variables.Design: A randomized controlled trial (RCT) of diets with a high glycemic load (HG) or a low glycemic load (LG) at 30% CR was conducted in 34 healthy overweight adults with a mean (+/- SD) age of 35 +/- 6 y and body mass index (kg/m(2)) of 27.6 +/- 1.4. All food was provided for 6 mo in diets controlled for confounding variables, and subjects self-administered the plans for 6 additional months. Primary and secondary outcomes included energy intake measured by doubly labeled water, body weight and fatness, hunger, satiety, and resting metabolic rate.Results: All groups consumed significantly less energy during CR than at baseline (P < 0.01), but changes in energy intake, body weight, body fat, and resting metabolic rate did not differ significantly between groups. Both groups ate more energy than provided (eg, 21% and 28% CR at 3 mo and 16% and 17% CR at 6 mo with HG and LG, respectively). Percentage weight change at 12 mo was -8.04 +/- 4.1% in the HG group and -7.81 +/- 5.0% in the LG group. There was no effect of dietary composition on changes in hunger, satiety, or satisfaction with the amount and type of provided food during CR.Conclusions: These findings provide more detailed evidence to suggest that diets differing substantially in glycemic load induce comparable long-term weight loss.