Anti-tuberculosis Compounds from Mallotus philippinensis
Anti-tuberculosis Compounds from Mallotus philippinensis
复制标题
菲律宾野桐的抗结核化合物
DOI：
10.1177/1934578x1000500208
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发表时间：
2010
影响因子：
1.8
通讯作者：
M. Reinecke
中科院分区：
文献类型：
--
作者：
Qi Hong;D. Minter;S. Franzblau;M. Arfan;Hazrat Amin;M. Reinecke
对菲律宾野桐的有机提取物进行生物测定定向分级分离，得到五种化合物（1-5），其中对结核分枝杆菌最具活性的是一种新化合物，8-肉桂酰基-5，7-二羟基-2，2-二甲基-6-香叶基色烯（1），建议将其命名为野桐F。化合物（2），8-肉桂酰基-2，2-二甲基-7-羟基-5-甲氧基色烯，为首次从天然植物中分离得到，其余三个化合物，rottlerin（3），isoallorottlerin=isorottlerin（4）和所谓的“红色化合物”，8-肉桂酰基-5，7-二羟基-2，2，6-三甲基色烯（5），以前已从该植物中分离得到。所有化合物通过分析其光谱（包括2D-NMR）来鉴定，2D-NMR用于校正化合物2-4的文献NMR光谱归属。首次报道了5的~（13）C NMR谱。
Bioassay-directed fractionation of the organic extract of Mallotus philippinensis gave five compounds (1-5), the most active of which against Mycobacterium tuberculosis was a new compound, 8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-6-geranylchromene (1) for which the name mallotophilippen F is suggested. Compound (2), 8-cinnamoyl-2,2-dimethyl-7-hydroxy-5-methoxychromene, was isolated from a natural source for the first time, while the remaining three compounds, rottlerin (3), isoallorottlerin=isorottlerin (4) and the so-called “red compound,” 8-cinnamoyl-5,7-dihydroxy-2,2,6-trimethylchromene (5), had been isolated previously from this plant. All compounds were identified by analysis of their spectra including 2D-NMR, which was used to correct the literature NMR spectral assignments of compounds 2-4. The C-13 NMR of 5 is reported for the first time.