Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand.
Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand.
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DOI：
10.1248/cpb.54.1530
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发表时间：
2006-11
影响因子：
1.7
通讯作者：
T. Morikawa;Feng-ming Xu;H. Matsuda;M. Yoshikawa
中科院分区：
文献类型：
--
作者：
T. Morikawa;Feng-ming Xu;H. Matsuda;M. Yoshikawa
从原产于泰国的扩张沙枣茎中分离得到一个新的黄烷醇和两个新的黄酮类成分E和F，其中一个为新的黄烷醇，另一个为红木素D。根据化学和物理化学证据，对新的黄酮类化合物进行了结构鉴定。此外，还考察了扩张棘豆中分离的化学成分对内毒素激活的小鼠巨噬细胞产生一氧化氮的抑制作用。在主要成分中，两种异黄酮类化合物克莱菌素(IC50=13微米)和鱼藤素B(18微米)和两种鱼藤烯类化合物鱼藤素(26微米)和鱼藤酮(27微米)具有较强的抑制活性。
A new flavanol, erycibenin D, and two new flavans, erycibenins E and F, were isolated from the stems of Erycibe expansa originating in Thailand. The structures of new flavonoids were elucidated on the basis of chemical and physicochemical evidence. In addition, the inhibitory activities of the isolated constituents from E. expansa on lipopolysaccharide-activated nitric oxide production in mouse peritoneal macrophages were examined. Among the principal constituents, two isoflavones, clycosin (IC50 = 13 microM) and erythrinin B (18 microM), and two rotenoids, deguelin (26 microM) and rotenone (27 microM), were found to show potent inhibitory activity.