The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
复制标题
在没有γ干扰素的情况下，细胞毒性T淋巴细胞对仙台病毒的反应不会受到损害。
DOI：
10.1128/jvi.71.3.1906-1910.1997
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Doherty,PC
中科院分区：
文献类型：
--
作者：
Mo,XY;Tripp,RA;Sangster,MY;Doherty,PC
仙台病毒在干扰素(干扰素)-/-BALB/c小鼠的呼吸道中以正常的动力学被消除。经支气管肺泡灌洗恢复的细胞群中病毒特异性细胞毒性T淋巴细胞(CTL)活性水平未受损害，产生白介素4(IL-4)细胞的比例增加，病毒特异性免疫球蛋白IgG1和IgG2b滴度在干扰素-γ/-小鼠中较高。在淋巴组织和肺炎肺中出现这种T-helper 2反应谱没有明显的有害后果。在CD4+亚群耗尽后，病毒清除略有延迟，对干扰素-伽马-/-和+/+小鼠的影响程度相似。然而，在缺乏同时存在的CD4+T细胞帮助的情况下，在干扰素-γ-/-(但不是+/+)小鼠中，CTL前体(CTLp)的产生减少。显然，在+/+小鼠中，CTLp群体的克隆性扩张既可以由干扰素-γ/-CD4+T细胞产生的细胞因子(可能是IL-2)促进，也可以由其他类型的细胞产生的干扰素-γ促进。
Sendai virus is eliminated from the respiratory tract of gamma interferon (IFN-gamma) -/- BALB/c mice with normal kinetics. The level of virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and the titers of virus-specific immunoglobulins IgG1 and IgG2b are higher in the IFN-gamma -/- mice. The emergence of this T-helper 2 response profile in both lymphoid tissue and the pneumonic lung has no obvious deleterious consequences. Virus clearance is slightly delayed following depletion of the CD4+ subset, with the effect being similar in magnitude for IFN-gamma -/- and +/+ mice. However, the generation of CTL precursors (CTLp) is diminished in the IFN-gamma -/- (but not +/+) mice in the absence of concurrent CD4+ T help. Apparently the clonal expansion of the CTLp population can be promoted either by a cytokine (perhaps IL-2) produced by the IFN-gamma -/- CD4+ T cells or by IFN-gamma made by other cell types in the +/+ mice.