Routine Adoption of Urinary [IGFBP7].[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
Routine Adoption of Urinary [IGFBP7].[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study
复制标题
DOI：
10.1038/s41598-019-52790-6
复制
发表时间：
2019-11-11
影响因子：
4.6
通讯作者：
Ronco, Claudio
中科院分区：
文献类型：
--
作者：
Ferrari, Fiorenza;Romero-Gonzalez, Gregorio;Ronco, Claudio
尿金属蛋白酶组织抑制剂2和胰岛素样生长因子结合蛋白7（[TIMP-2]. [IGFBP 7]），以改善测量后12小时内严重急性肾损伤（阿基）的风险预测。我们进行了一项前瞻性队列研究，以评估[TIMP-2]的预测价值。阿基的[IGFBP 7]可能在12小时后继续。我们从2016年6月至12月招募了442名重症成人患者。在入院时采集尿液样本用于[TIMP-2]。[IGFBP 7]测量。记录患者的基线特征，包括患者的人口统计学资料、既往健康史和入院的主要原因，以建立logistic回归模型来预测阿基。[TIMP-2]患者之间的阿基发生率不同。[IGFBP 7] 0.3（ng/ml）2/1000（分别为31.9%和68.10%; p
The urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 ([TIMP-2].[IGFBP7]) have been introduced to improve risk prediction of severe acute kidney injury (AKI) within 12 hours of measurement. We performed a prospective cohort study to evaluate if the predictive value of [TIMP-2].[IGFBP7] for AKI might continue after 12 hours. We enrolled 442 critically ill adult patients from June to December 2016. Urine samples were collected at admission for [TIMP-2].[IGFBP7] measurement. Baseline patient characteristics were recorded including patients' demographics, prior health history, and the main reason for admission to build a logistic regression model to predict AKI. AKI occurrence differed between patients with [TIMP-2].[IGFBP7] 0.3 (ng/ml)2/1000 (31.9% and 68.10% respectively; p