Tetrapeptide-Based Hydrogels: for Encapsulation and Slow Release of an Anticancer Drug at Physiological pH
Tetrapeptide-Based Hydrogels: for Encapsulation and Slow Release of an Anticancer Drug at Physiological pH
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DOI：
10.1021/jp904251j
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发表时间：
2009-09-03
影响因子：
3.3
通讯作者：
Banerjee, Arindam
中科院分区：
文献类型：
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作者：
Naskar, Jishu;Palui, Goutam;Banerjee, Arindam
在这里，我们报告了两种基于合成寡肽的、热可逆的、pH 敏感的水凝胶。在凝胶相中，这些自组装四肽形成长互连的纳米纤维网络结构，这从各种显微技术中可以明显看出，包括场发射扫描电子显微镜（FE-SEM）、透射电子显微镜（TEM）和原子力显微镜（AFM）。 FTIR、圆二色性和广角 X 射线衍射 (WAXD) 有利于这些凝胶剂在凝胶状态下的反平行 β 片层结构。最后，这些水凝胶已被用于在生理pH值下包埋和缓慢释放抗癌药物阿霉素，有望作为药物输送载体的未来应用。
Here, we report two synthetic oligopeptide-based, thermoreversible, pH-sensitive hydrogels. In gel phase, these self-assembling tetrapeptides form a long interconnected nanofibrilar network structure, as is evident from various microscopic techniques, including field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). FTIR, circular dichroism, and wide angle X-ray diffraction (WAXD) favor an antiparallel beta-sheet structure of these gelators in the gel state. Finally, these hydrogels have been utilized for entrapment and slow release of an anticancer drug doxorubicin at physiological pH, promising their future application as a drug delivery vehicle.