Chronic cerebrovascular dysfunction after traumatic brain injury.
Chronic cerebrovascular dysfunction after traumatic brain injury.
复制标题
DOI：
10.1002/jnr.23732
复制
发表时间：
2016-07
影响因子：
4.2
通讯作者：
Badaut J
中科院分区：
文献类型：
--
作者：
Jullienne A;Obenaus A;Ichkova A;Savona-Baron C;Pearce WJ;Badaut J
创伤性脑损伤（TBI）通常涉及血管功能障碍，导致大脑生理和认知功能的长期改变。事实上，所有形成血管并参与维持其正常功能的细胞都可能被创伤性脑损伤改变。在这篇综述中，我们关注脑外伤后发生的不同类型的脑血管功能障碍，包括脑血流（CBF）改变、自身调节障碍、蛛网膜下腔出血（SAH）、血管痉挛、血脑屏障（BBB）破坏和水肿形成。我们还讨论了介导这些功能障碍的机制，重点关注脑血管的细胞成分（内皮细胞、平滑肌细胞、星形胶质细胞、周细胞、血管周围神经）及其在继发性损伤级联中的已知和潜在作用。外伤性脑损伤可引起脑血流量减少、自身调节功能受损、蛛网膜下腔出血、血管痉挛、水肿、血脑屏障破坏和长期神经变性等脑血管功能改变。本文就内皮细胞、平滑肌细胞、星形胶质细胞和血管周围神经支配在这些损伤级联中的作用作一综述。
Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to longterm alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. In this review, we focus on the different types of cerebrovascular dysfunction that occur after TBI, ranging from cerebral blood flow (CBF) alterations, autoregulation impairments, subarachnoid hemorrhage (SAH), vasospasms, blood-brain barrier (BBB) disruption and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade. Traumatic brain injuries lead to alteration of cerebrovascular function by inducing decreased cerebral blood flow, impaired autoregulation, subarachnoid hemorrhage, vasospasms, edema, blood-brain barrier disruption and long-term neurodegeneration. The roles of endothelial cells, smooth muscle cells, astrocytes, and perivascular innervation in these injury cascades are discussed in this review.