Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression.
Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression.
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DOI：
10.1007/s40473-017-0115-8
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发表时间：
2017-06-01
影响因子：
1.7
通讯作者：
Coccaro, Emil F
中科院分区：
文献类型：
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作者：
Fanning, Jennifer R;Keedy, Sarah;Coccaro, Emil F
审查目的：攻击性行为在许多自然环境中具有适应性价值；然而，它给人类社会带来了沉重的负担和成本。出于这个原因，长期以来，人们一直对了解攻击性的神经生物学基础感兴趣。这种兴趣以及神经影像学研究的蓬勃发展，刺激了有关该主题的大量且不断增长的科学文献的发展。因此，出现了一种攻击性行为的神经回路模型，该模型暗示了涉及情绪反应、情绪调节和认知控制的相互关联的大脑区域。最近的发现：最近，模拟挑衅性互动的行为范式已适应神经成像协议，为直接探测神经回路在攻击性互动中的参与提供了机会。在这里，我们回顾了研究志愿者模拟攻击性互动的神经影像学研究。我们重点研究使用经过充分验证的实验室范式来进行反应性身体攻击，并检查挑衅、报复和评估对手惩罚的神经相关性。总结：总体而言，所回顾的研究支持支持情绪反应、情绪调节和认知控制的神经回路参与攻击行为。基于对这些文献的综合，讨论了未来的研究方向。
PURPOSE OF REVIEW: Aggressive behavior has adaptive value in many natural environments; however, it places substantial burden and costs on human society. For this reason, there has long been interest in understanding the neurobiological basis of aggression. This interest, and the flourishing of neuroimaging research in general, has spurred the development of a large and growing scientific literature on the topic. As a result, a neural circuit model of aggressive behavior has emerged that implicates interconnected brain regions that are involved in emotional reactivity, emotion regulation, and cognitive control.RECENT FINDINGS: Recently, behavioral paradigms that simulate provocative interactions have been adapted to neuroimaging protocols, providing an opportunity to directly probe the involvement of neural circuits in an aggressive interaction. Here we review neuroimaging studies of simulated aggressive interactions in research volunteers. We focus on studies that use a well-validated laboratory paradigm for reactive physical aggression and examine the neural correlates of provocation, retaliation, and evaluating punishment of an opponent.SUMMARY: Overall, the studies reviewed support the involvement of neural circuits that support emotional reactivity, emotion regulation, and cognitive control in aggressive behavior. Based on a synthesis of this literature, future research directions are discussed.