EFFECT OF RESIDUAL INSULIN-SECRETION ON EXOCRINE PANCREATIC FUNCTION IN JUVENILE-ONSET DIABETES-MELLITUS
EFFECT OF RESIDUAL INSULIN-SECRETION ON EXOCRINE PANCREATIC FUNCTION IN JUVENILE-ONSET DIABETES-MELLITUS
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DOI：
10.1007/bf01223020
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发表时间：
1978-01-01
期刊：
影响因子：
8.2
通讯作者：
ELLIOTT, HL
中科院分区：
文献类型：
--
作者：
FRIER, BM;FABER, OK;ELLIOTT, HL
通过测量空腹和静脉注射后的血清C肽免疫反应性(CPR)，研究了18名青少年发病的糖尿病患者的残余β细胞功能。注射胰高血糖素（1 毫克）。这与外分泌胰腺对静脉注射的反应进行了比较。输注促胰液素和胆囊收缩素-胰酶。测量了胰腺碳酸氢盐、淀粉酶和胰蛋白酶的输出。 14 名患者的外分泌胰腺功能下降。空腹和最大心肺复苏显示 9 名患者有残余胰岛素分泌。对于这些 CPR 分泌者，CPR 与碳酸氢盐（r = 0.87，P < 0.005）和淀粉酶（r = 0.7，P < 0.05）的输出之间存在很强的相关性，但与胰蛋白酶无关。这些结果表明胰腺中存在内分泌-外分泌关系。
Residual .beta.-cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting and after i.v. injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an i.v. infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bicarbonate, amylase and trypsin were measured. Exocrine secretory pancreatic function was decreased in 14 patients. Fasting and maximal CPR showed that 9 patients had residual insulin secretion. For these CPR-secretors there was a strong correlation between CPR and output of bicarbonate (r = 0.87, P < 0.005) and amylase (r = 0.7, P < 0.05), but not with trypsin. These results suggest the existence of an endocrine-exocrine relationship in the pancreas.