Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding
Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding
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DOI：
10.4161/pri.3.2.8820
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发表时间：
2009-04-01
期刊：
影响因子：
2.3
通讯作者：
Hanger, Diane P.
中科院分区：
文献类型：
--
作者：
Noble, Wendy;Garwood, Claire J.;Hanger, Diane P.
许多神经退行性疾病具有共同的特征，包括聚集的错误折叠蛋白的积累、神经炎症和诱导细胞凋亡。虽然这些单独的元素中的每一个对神经元死亡的贡献仍然不清楚，但在几种神经退行性疾病模型中，一种常用的抗生素米诺环素已被证明可以通过下调这些分子途径来减少疾病的进展和严重程度。在这里，我们讨论的证据米诺环素作为一种广泛的特异性治疗剂的神经退行性疾病的特点是存在错误折叠的蛋白质的潜力。
Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.