Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function.
Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function.
复制标题
解偶联蛋白 3 (UCP3)：寻找功能的线粒体载体。
DOI：
10.1038/sj.ijo.0800943
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lowell,BB
中科院分区：
文献类型：
--
作者：
Lowell,BB
UCP 3是一种线粒体蛋白，与已建立的解偶联蛋白UCP 1具有高度同源性。它与UCP 1的高度同源性表明UCP 3可能是一个真正的解偶联蛋白。初步生物化学研究与具有解偶联活性的UCP 3一致。然而，需要详细的功能研究来了解UCP 3的真正生物化学和生理目的。这些努力应该通过鉴定具有失活突变的人类和/或产生缺乏UCP 3的基因敲除小鼠来辅助。
UCP3 is a mitochondrial protein with high homology to the established uncoupling protein, UCP1. Its high degree of homology to UCP1 suggests that UCP3 may be a true uncoupling protein. Preliminary biochemical studies are consistent with UCP3 having uncoupling activity. However, detailed functional studies are required to understand the true biochemical and physiological purpose of UCP3. These efforts should be aided by identification of humans with inactivating mutations and/or the generation of gene knockout mice lacking UCP3.