Fetal Development of the Incisive Canal, Especially of the Delayed Closure Due to the Nasopalatine Duct: A Study Using Serial Sections of Human Fetuses.
Fetal Development of the Incisive Canal, Especially of the Delayed Closure Due to the Nasopalatine Duct: A Study Using Serial Sections of Human Fetuses.
复制标题
切牙管的胎儿发育，特别是鼻腭管导致的延迟闭合：一项使用人类胎儿连续切片的研究。
DOI：
10.1002/ar.23521
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hwang HP.
中科院分区：
文献类型：
--
作者：
Kim JH;Oka K;Jin ZW;Murakami G; Rodriguez-Vazquez JF;Ahn SW;Hwang HP.
切骨或前颌骨的切开管是一条穿过鼻腭神经及其伴行血管的狭窄的骨管。然而，它的胎儿发育仍然模糊不清。本文对26例胎龄9~20周(头臀长46~183 mm)的胎儿头部进行了连续的头颅切片检查，以评估胎儿的发育。神经最初穿过一个宽阔的松散的组织间隙，但在12-15周的时候，切口骨的上部骨化后，管子变得狭窄，充满了致密的纤维组织。7例胎儿单侧或双侧管腔扩张开放。在这七个胎儿中的两个，鼻腭管穿过管道，将鼻腔连接到切开颅窝内副正中上皮珍珠的中央管腔(而不是口腔)。即使运河被关闭，管道也可能保持在关闭部分的上方和下方。所有大于110 mm(15周)的标本中都有旁中线珍珠，有或没有中线珍珠的联系。这些旁正中的珍珠通常向扩张的或开放的运河伸出和/或延伸到其中，这表明这些珍珠，而不是任何原始的口鼻沟通途径，有助于保持运河的开放。扩张的牙管位于第二和第三个牙蕾的超内侧，似乎通常由于进一步的骨化而闭合。即使在胎儿中，鼻腭管似乎是一个变异的或不寻常的发育阶段，在正常的上颌融合后暂时发生。Anat Rec，300：1093-1103,2017。©2016 Wiley期刊，Inc.
The incisive canal of the incisive bone or premaxilla is a narrow bony canal through which pass the nasopalatine nerve and its concomitant vessels. However, its fetal development remains obscure. To assess its development, serial frontal sections of the heads of 26 human fetuses, of gestational age 9–20 weeks (crown‐rump length, 46–183 mm), were examined. The nerve initially passed through a wide loose tissue space, but after ossification of the upper part of the incisive bone at 12–15 weeks, the canal became narrow and filled with tight fibrous tissue. Canals in seven fetuses were dilated and open unilaterally or bilaterally. In two of these seven fetuses, a nasopalatine duct passed through the canal and connected the nasal cavity to a central lumen of the paramedian epithelial pearl in the incisive fossa (not to an oral cavity). Even if the canal was closed, the duct was likely to remain above and below the closed part. Paramedian pearls were present in all specimens larger than 110 mm (15 weeks), with or without association of midline pearls. These paramedian pearls usually protruded toward and/or extended into the dilated or open canal, suggesting that these pearls, not any primitive oronasal communication pathway, contributed to keeping the canal open. The dilated canal, located on the superomedial side of the second and third teeth buds, seemed to be usually closed by further ossification. Even in fetuses, the nasopalatine duct seemed to be a variant or unusual phase of development temporally occurring after normal palate fusion. Anat Rec, 300:1093–1103, 2017. © 2016 Wiley Periodicals, Inc.