Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro.
Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro.
复制标题
血红胺化学结构的微小变化会极大地影响其衍生物对瘤胃体外发酵的影响。
DOI：
10.1038/s41598-019-38977-x
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Ramos-Morales E
中科院分区：
文献类型：
--
作者：
Ramos-Morales E
尽管植物提取物通过肠道发酵提高饲料效率和动物生产力以及减少甲烷排放的潜力已被证明，但现有的信息往往是矛盾的，这归因于生物活性化合物的复杂混合物及其相互作用的差异。了解化合物的结构特征可能影响提取物的生物活性的程度至关重要。我们假设化合物结构中相对较小的变化可能会对衍生物改变瘤胃发酵的能力产生重大影响。从天然生物碱血红胺合成了九种化合物，并在体外测试了它们对瘤胃原生动物和发酵参数的影响。我们的结果表明，血红胺或其衍生物二氢血红胺与乙酸酯、丁酸酯、新戊酸酯或己酸酯的简单酯化产生的化合物对瘤胃发酵的影响不同。
Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and testedin vitrofor their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation.