New phenolics, cytotoxicity and chemosystematic significance of Atriplex semibaccata
New phenolics, cytotoxicity and chemosystematic significance of Atriplex semibaccata
复制标题
DOI：
10.1016/j.phytol.2019.09.016
复制
发表时间：
2019-12-01
影响因子：
1.7
通讯作者：
Hegazy, Mohamed-Elamir F.
中科院分区：
文献类型：
--
作者：
Elshamy, Abdelsamed, I;Mohamed, Tarik A.;Hegazy, Mohamed-Elamir F.
从藜科植物半叶滨藜的70%乙醇提取物中分离得到一个新的甲氧基黄酮三糖苷A(1)和一个新的木脂酰胺(N-[(E)-m-羟基肉桂酰基]酪胺)(7)，以及5个已知的黄酮醇(2-6)和2个木脂酰胺(8-9)。通过LR和HR-FAB-MS、一维和二维核磁共振波谱分析确定了化合物的结构。对分离得到的化合物(1-4和7-9)进行了细胞毒活性研究。化合物7、8和9对白血病CCRF-CEM细胞有微弱的增殖抑制作用，IC50值分别为78.5、46.3和71.2 mU g/ml，对Hela和HSC-2癌细胞无细胞毒作用。根据半叶滨藜的化学成分与其他滨藜的化学成分进行比较，对化学系统学意义进行了评价。
The chemical characterization of the 70% hydromethanolic extract of Atriplex semibaccata (family: Chenopodiaceae) afforded a new methoxylated flavonol triglycoside, atrisemibaccatoside A (1), and a new lignanamide, (N-[(E)-m-hydroxycinnamoyl]tyramine (7), as well as, five known flavonols (2-6) and two lignanamides (8-9). The structures of the isolated compounds were established depending upon LR&HR-FAB-MS, 1D and 2D NMR spectroscopic analyses. The cytotoxic activity of the isolated compounds (1-4, and 7-9) was investigated. Compounds 7, 8 and 9 weakly inhibited the proliferation of leukemia CCRF-CEM cells with IC50 values of 78.5, 46.3, and 71.2 mu g/ml, respectively, and exhibited no cytotoxicity against Hela and HSC-2 cancer cells. A chemosystematic significance study was evaluated depending upon the chemical constituents of A. semibaccata comparing with those of other Atriplex species.