Hypertension among adults exposed to drinking water arsenic in Northern Chile
Hypertension among adults exposed to drinking water arsenic in Northern Chile
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DOI：
10.1016/j.envres.2016.11.016
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发表时间：
2017-02-01
影响因子：
8.3
通讯作者：
Steinmaus, Craig M.
中科院分区：
文献类型：
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作者：
Hall, Emily M.;Acevedo, Johanna;Steinmaus, Craig M.
背景：越来越多的研究发现无机砷暴露与高血压之间存在关联。然而，研究结果并不一致。额外的研究是必要的，由于砷暴露和发病率归因于hypertension.Methods的全球患病率：我们分析了从2007年10月至2010年12月在智利北方的人口为基础的癌症病例对照研究收集的数据。数据包括终生个人砷暴露估计和信息的潜在混杂因素，共1266名受试者。那些自我报告医生诊断为高血压或使用抗高血压药物的患者被归类为高血压患者（n=612）。结果：与最低类别人群相比，最高5年平均砷暴露水平显著高于最低类别人群，高血压与饮水砷暴露水平显著相关（P <0.05），高血压与饮水砷暴露水平显著相关（< 60 μ g/L），中部（60-623 μ g/L）和较高（> 623 μ g/L）暴露类别的校正高血压OR分别为1.49（95% CI：1.09，2.05）和1.65（95% CI：1.18，2.32）。在分析中观察到类似的结果，终生累积暴露和分析仅限于暴露从遥远的paste.Conclusions：我们确定的证据表明，高血压的几率增加与暴露于饮用水中的砷的研究参与者。我们的发现增加了支持这种关联的越来越多的研究，这可能具有重要的公共卫生意义。
Background: A growing number of studies have identified an association between exposure to inorganic arsenic and hypertension. However, results have not been consistent across studies. Additional studies are warranted, given the global prevalence of both arsenic exposure and morbidity attributable to hypertension.Methods: We analyzed data collected from October 2007-December 2010 for a population-based cancer case control study in northern Chile. Data included lifetime individual arsenic exposure estimates and information on potential confounders for a total of 1266 subjects. Those self-reporting either a physician diagnosis of hypertension or use of an anti-hypertensive medication were classified as having hypertension (n=612). The association between hypertension and drinking water arsenic exposure was analyzed using logistic regression models.Results: Compared to those in the lowest category for lifetime highest 5-year average arsenic exposure (< 60 mu g/L), those in the middle (60-623 mu g/L) and upper (> 623 mu g/L) exposure categories had adjusted hypertension ORs of 1.49 (95% CI: 1.09, 2.05) and 1.65 (95% CI: 1.18, 2.32), respectively. Similar results were observed in analyses of lifetime cumulative exposures and analyses restricted to exposures from the distant past.Conclusions: We identified evidence of increased odds of hypertension with exposure to arsenic in drinking water among study participants. Our findings add to the growing body of research supporting this association, which could have important public health implications.