Diffusion, dimensionality, and noise in transcriptional regulation.
Diffusion, dimensionality, and noise in transcriptional regulation.
复制标题
DOI：
10.1103/physreve.79.051901
复制
发表时间：
2007-12
期刊：
影响因子：
--
通讯作者：
G. Tkačik;W. Bialek
中科院分区：
文献类型：
--
作者：
G. Tkačik;W. Bialek
生物化学信号的精确性受到分子扩散到达其目标的随机性的限制。对于与DNA上的特定位点结合并调节转录的蛋白质，除了它们在本体溶液中的扩散之外，蛋白质通过沿DNA的长度沿着滑动而在一维中扩散的能力似乎会产生更大的DNA结合靶，从而降低在调节位点占据中的噪声。在这里，我们表明，这种效果在很大程度上取消了增强的时间相关性在一维扩散。在现实的参数下，DNA的沿着滑动对转录调控精确度的物理限制几乎没有影响。
The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to specific sites on DNA and regulating transcription, the ability of the proteins to diffuse in one dimension by sliding along the length of the DNA, in addition to their diffusion in bulk solution, would seem to generate a larger target for DNA binding, consequently reducing the noise in the occupancy of the regulatory site. Here we show that this effect is largely canceled by the enhanced temporal correlations in one-dimensional diffusion. With realistic parameters, sliding along DNA has surprisingly little effect on the physical limits to the precision of transcriptional regulation.