Heart rate variability during artificial ventilation and apnea in brain-damaged rabbits.
Heart rate variability during artificial ventilation and apnea in brain-damaged rabbits.
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脑损伤兔子在人工通气和呼吸暂停期间的心率变异性。
DOI：
10.1152/ajpheart.1996.271.2.h410
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
O. Yuge,
中科院分区：
文献类型：
--
作者：
M. Kawamoto;K. Kaneko;Hardian;O. Yuge,
在脑损伤家兔中测定了人工通气、呼吸暂停和去甲肾上腺素给药对心率变异性的影响。心电图R-R间期和循环变量在三个不同的呼吸频率，包括呼吸暂停异氟醚全身麻醉下测量5分钟。在通过膨胀的颅内球囊造成脑损伤后重复相同的测量。在对照兔（n = 8）和接受去甲肾上腺素的兔（n = 8）中，重复R-R间期的功率谱分析，并评估低（LF：0.04-0.09 Hz）、中（MF：0.09-0.15 Hz）和高（HF：0.15-0.40 Hz）频带面积的谱分量。LF + MF在呼吸暂停时增加（P < 0.05），而HF在全麻时无变化。脑损伤后两组LF + MF无明显变化，HF降低（P < 0.05）。两组在呼吸暂停时HF/（LF + MF）的降低无显著性差异（P> 0.05）。去甲肾上腺素增加心率和动脉压（P < 0.05），但在频谱成分上没有产生任何组间差异。我们认为，交感迷走神经平衡在全麻下呼吸暂停时倾向于交感紧张，而在脑损伤时则倾向于迷走神经阻滞。
The effect of artificial ventilation, apnea, and norepinephrine administration on heart rate variability was determined in brain-damaged rabbits. Electrocardiographic R-R intervals and circulatory variables were measured for 5 min at three different ventilatory frequencies, including apnea under isoflurane general anesthesia. The same measurements were repeated after brain damage was inflicted by an inflated intracranial balloon. In control rabbits (n = 8) and in those receiving norepinephrine (n = 8), power spectral analysis of R-R intervals was repeated, and spectral components of low (LF: 0.04-0.09 Hz), mid (MF: 0.09-0.15 Hz), and high (HF: 0.15-0.40 Hz) frequency band areas were assessed. LF + MF (P < 0.05) increased during apnea, whereas HF did not change under general anesthesia. However, after brain damage in both groups LF + MF did not change, whereas HF was depressed (P < 0.05). There was no intergroup difference in decreases of HF/(LF + MF) (P < 0.05) during apnea under either condition. Norepinephrine increased heart rate and arterial pressure (P < 0.05) but did not produce any intergroup difference in the spectral components. We suggest that sympathovagal balance is apt to be sympathotonic during apnea under general anesthesia, whereas it is vagolytic with brain damage.