p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease
p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease
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DOI：
10.1007/s10620-007-9886-1
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Rubin, David T.
中科院分区：
文献类型：
--
作者：
Nathanson, Jeffrey W.;Yadron, Nicole E.;Rubin, David T.
背景资料：肿瘤抑制基因p53的突变与溃疡性结肠炎中的肿瘤形成有关，但对其在克罗恩病（CD）中的意义了解甚少。目的：探讨p53蛋白表达作为CD患者肿瘤发生的标志物。方法：这是一个回顾性的CD患者谁接受p53免疫组化染色在我们的中心在1995年至2003年。p53状态与染色时和随后随访时肿瘤的存在和级别相关。结果：14例CD患者进行了p53评估：8例p53阳性，6例p53阴性。8例p53+中有7例有异型增生（6例LGD，1例HGD）; 6例p53-中有1例有异型增生（LGD）（P = 0.03）。4例p53+患者随访时出现持续性异型增生，2例进展至更高级别。3例p53-患者随访时仍无异型增生。结论：这项有限的研究表明，CD患者中p53的过度表达与异型增生相关，随着时间的推移，异型增生可能进展为更高级别的瘤形成。
Background: Mutations in the tumor suppressor gene p53 are associated with neoplasia in ulcerative colitis, but little is understood of their significance in Crohn's disease (CD). Purpose: To explore p53 expression as a marker of neoplasia in CD patients. Methods: This is a retrospective review of CD patients who underwent p53 IHC staining in our center between 1995 and 2003. The p53 status was correlated to the presence and grade of neoplasia at the time of staining and in subsequent follow-up. Results: Fourteen CD patients had p53 assessment: eight were p53 positive and six were p53 negative. Seven of eight p53+ had dysplasia (six LGD, one HGD); one of six p53-had dysplasia (LGD) (P = 0.03). Four p53+ patients with follow-up had persistent dysplasia and two had progression to a higher grade. Three p53- patients with follow-up remained free of dysplasia. Conclusions: This limited study shows that p53 over expression in CD patients is associated with dysplasia that may progress to a higher grade of neoplasia over time.