Future studies using histomorphometry in type 1 diabetes mellitus.
Future studies using histomorphometry in type 1 diabetes mellitus.
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DOI：
10.1097/med.0000000000000644
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发表时间：
2021-08-01
期刊：
影响因子：
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通讯作者：
Recker RR
中科院分区：
文献类型：
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作者：
Graeff-Armas LA;Silverman E;Recker RR
本文综述了1型糖尿病与骨的研究现状，重点介绍了人骨转换标志物和组织形态计量学方面的研究进展。几十年来，骨转换标志物一直被用来记录各种疾病的静态骨转换状态，尤其是糖尿病。两项新的研究集中在动态测试条件下，以检验胰岛素和运动对骨转换的急性影响。关于1型糖尿病患者骨组织形态计量学的文献很少，但目前有几项新的研究正在进行中。在这里，我们回顾了关于人骨转换标志物和组织形态计量学的最新文献。骨转换低被认为是T1 DM患者骨脆性的一个主要潜在因素。对人类暂时性骨活检的进一步研究将有助于确定其机制。
This article reviews the current state of research in Type 1 Diabetes and bone, focusing on human bone turnover markers and histomorphometry. Bone turnover markers have been used for decades to document static bone turnover status in a variety of diseases, but especially in diabetes. Two new studies focus on dynamic testing conditions to examine the acute effects of insulin and exercise on bone turnover. Publications of human bone histomorphometry in Type 1 Diabetes are few, but there are several new studies currently underway. Here, we review the most recent literature on human bone turnover markers and histomorphometry. Low bone turnover is thought to be a major underlying factor in bone fragility in T1DM. Further studies in human transilial bone biopsies will be helpful in determining the mechanisms.