Age-related changes in EGF and protease in submandibular glands of C57BL/6J mice.
Age-related changes in EGF and protease in submandibular glands of C57BL/6J mice.
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C57BL/6J 小鼠下颌下腺中 EGF 和蛋白酶的年龄相关变化。
DOI：
10.1080/03610738208258402
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发表时间：
1982
影响因子：
1.8
通讯作者：
Azmitia,E
中科院分区：
文献类型：
--
作者：
Gresik,EW;Brennan,M;Azmitia,E
对以下年龄（月龄）的雄性C57 BL/6 J小鼠的颌下腺进行了细胞学和化学研究：1-1.5、6-8、12-13、28-32。颗粒曲小管（GCT）的相对比例以及GCT细胞分泌颗粒的大小和含量在整个生命的第一年逐渐增加。相应地，两个GCT细胞产物，表皮生长因子（EGF）和蛋白酶的腺体内的浓度也稳步增加。在衰老的腺体中，GCT形成的腺体实质相对较少，由分泌颗粒量减少的较短细胞组成。EGF的浓度在一年时下降到其峰值的17%，而蛋白酶活性下降到其峰值的50%。这些形态学和化学的发现暗示了衰老小鼠颌下腺的功能受损。
The submandibular glands of male C57BL/6J mice were studied cytologically and chemically at the following ages (months): 1–1.5, 6–8, 12–13, 28–32. The relative proportion of granular convoluted tubules (GCT) as well as the size and content of secretion granules of GCT cells, progressively increased throughout the first year of life. Correspondingly, the concentration within the glands of two GCT cell products, epidermal growth factor (EGF) and protease, also steadily increased. In senescent glands, GCTs formed relatively less of the gland parenchyma and were composed of shorter cells with reduced amounts of secretory granules. The concentration of EGF was reduced to 17% of its peak value at one year, while protease activity declined to 50% of its peak value. These morphologic and chemical findings imply a functional impairment in submandibular glands of the mouse with senescence.