Synthesis of thermoplastic poly(2-methoxyethyl acrylate)-based polyurethane by RAFT and condensation polymerization
Synthesis of thermoplastic poly(2-methoxyethyl acrylate)-based polyurethane by RAFT and condensation polymerization
复制标题
RAFT法和缩聚法合成热塑性聚丙烯酸2-甲氧基乙酯基聚氨酯
DOI：
10.1002/marc.202000346
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发表时间：
2020
影响因子：
4.6
通讯作者：
Atsushi Hotta
中科院分区：
文献类型：
--
作者：
Shunsuke Tazawa;Tomoki Maeda;Masamitsu Nakayama;Atsushi Hotta
分别采用端羟基加成-断裂链转移（RAFT）试剂和二异氰酸酯，通过可逆RAFT聚合和缩聚反应合成了热塑性固体聚（丙烯酸2-甲氧基乙酯）（PMEA）基聚氨酯（PU）。纯PMEA是一种很有前途的医用抗血栓液体。在低于72 °C的温度下通过动态力学分析（DMA）证实了基于PMEA的固体PU由于氢键而具有的热塑性。还通过血小板粘附试验分析了基于PMEA的PU的抗血栓形成特性。基于PMEA的PU上的血小板数量为每单位面积17个细胞，小于氟化类金刚石碳（F-DLC）上的血小板数量，F-DLC是一种众所周知的高度抗血栓形成材料。可以得出结论，新合成的PMEA基PU具有热塑性特征，具有优异的抗血栓性。
Thermoplastic solid poly(2‐methoxyethyl acrylate) (PMEA)‐based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl‐terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA‐based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA‐based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA‐based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond‐like carbon (F‐DLC), a well‐known highly antithrombogenic material. It is concluded that a newly synthesized PMEA‐based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.