RELATIONSHIP OF INTRINSIC CONNECTIONS TO FORELIMB MOVEMENT REPRESENTATIONS IN MONKEY MOTOR CORTEX - A CORRELATIVE ANATOMIC AND PHYSIOLOGICAL STUDY
RELATIONSHIP OF INTRINSIC CONNECTIONS TO FORELIMB MOVEMENT REPRESENTATIONS IN MONKEY MOTOR CORTEX - A CORRELATIVE ANATOMIC AND PHYSIOLOGICAL STUDY
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DOI：
10.1152/jn.1991.66.2.390
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发表时间：
1991-08-01
影响因子：
2.5
通讯作者：
JONES, EG
中科院分区：
文献类型：
--
作者：
HUNTLEY, GW;JONES, EG
1. 采用皮质内微刺激（ICMS）和辣根过氧化物酶（HRP）组化方法，研究了内在连接与皮质内微刺激部位诱发成年猕猴前肢运动皮层运动表征的关系。在麻醉状态下，刺激诱发的单个前肢关节运动的部位分布在动物之间有很大差异。相同的运动常常可以从多个不连续的地点引起。在引起拇指运动的部位注射单次小细胞外HRP后，发现小群逆行标记的细胞和密集的轴突末端斑块散布在前肢的广泛区域。末端斑块不连续，起源于水平的皮质内轴突。将HRP标记与生理上定义的运动图相关联，揭示了一组丰富的内在双向连接，这些连接将手指表征与手腕、肘部和肩部的运动表征联系起来。将HRP注射到靠近生理定义的面部表征的前肢表征中，几乎没有逆行标记的细胞或末梢纤维标记进入面部表征。其他作者的前外侧贴标片可能是游离的前外侧臂区。综上所述，这些数据表明，广泛的、水平定向的、内在的轴突侧枝为许多不同的前肢运动表征提供输入，并可能在复杂运动中被招募，以协调运动皮质区的活动，其主要输出是同步作用的前肢肌肉群。
1. Intracortical microstimulation (ICMS) and horseradish peroxidase (HRP) histochemistry were combined to examine the relationship between intrinsic connections and intracortical microstimulation sites eliciting evoked movements in the forelimb representation of adult macaque monkey motor cortex.2. The distribution of sites from which stimulation-evoked movements about individual forelimb joints were elicited under anesthesia varied considerably among animals. Identical movements could often be elicited from multiple, noncontiguous sites.3. After single, small extracellular HRP injections at sites from which thumb movement was evoked, small groups of retrogradely labeled cells and dense patches of axon terminations were found scattered across a wide area of the forelimb representation. Terminal patches were discontinuous and arose from horizontal, intracortical axons.4. Correlating the HRP labeling with the physiologically defined movement maps revealed a profuse set of intrinsic, bidirectional connections that connect digit representations and representations of movements about the wrist, elbow, and shoulder.5. HRP injections placed in the forelimb representation close to the physiologically defined face representation resulted in virtually no retrogradely labeled cells or terminal fiber labeling that crossed into the face representation. A patch of anterolaterally placed label that was present may be the dissociated rostrolateral arm area of other authors.6. Taken together, these data suggest that extensive, horizontally oriented, intrinsic axon collaterals provide inputs to many different forelimb movement representations and may be recruited during complex movements to coordinate the activity of motor cortical zones whose predominant output is to forelimb muscle groups acting synchronously.