LOCALIZED ALTERATIONS IN PRESYNAPTIC AND POSTSYNAPTIC SEROTONIN BINDING-SITES IN THE VENTROLATERAL PREFRONTAL CORTEX OF SUICIDE VICTIMS
LOCALIZED ALTERATIONS IN PRESYNAPTIC AND POSTSYNAPTIC SEROTONIN BINDING-SITES IN THE VENTROLATERAL PREFRONTAL CORTEX OF SUICIDE VICTIMS
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DOI：
10.1016/0006-8993(95)00523-s
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发表时间：
1995-08-07
期刊：
影响因子：
2.9
通讯作者：
MANN, JJ
中科院分区：
文献类型：
--
作者：
ARANGO, V;UNDERWOOD, MD;MANN, JJ
据报道，自杀受害者的大脑中5-羟色胺指数发生了变化。我们试图定位突触前和突触后5-羟色胺受体的变化，并确定可能影响自杀风险的前额叶皮质区域。在前额叶皮质的冠状切片上进行定量放射自显影，以确定自杀者的5-HT1a受体(突触后)和5-羟色胺转运体(突触前)结合是否与对照组不同。自杀组10 3个取样区中有85个5-HT1a受体结合率较高(n=18对；P<；0.0001)。增幅从17%到30%不等。这种增加在腹外侧额叶皮质更为明显。在43个样本区域(n=22对；P<；0.0001)中，自杀组的5-羟色胺转运体结合量在除一个区域外的所有区域中都较低。结合的减少在腹外侧额叶皮质最明显，自杀者和对照组之间的差异在15%到27%之间。5-羟色胺转运体与5-HT1a结合在同一脑区呈负相关(r=-0.35~-0.44，P=0.04~0.007)，提示共同的调节因素对这两种受体的结合具有相反的作用。我们得出结论，自杀受害者的5-羟色胺系统存在异常，主要涉及腹外侧额叶皮质，并假设该脑区的5-羟色胺能功能障碍与自杀行为的风险有关。
Altered serotonin indices have been reported in the brain of suicide victims. We sought to localize the changes in presynaptic and postsynaptic serotonin receptors and identify an area of prefrontal cortex that may influence suicide risk. Quantitative autoradiography was performed in coronal sections of prefrontal cortex to determine whether serotonin 5-HT1A receptor (postsynaptic in cortex) and serotonin transporter (presynaptic) binding are different in suicide victims compared to matched controls. 5-HT1A receptor binding was higher in 85 of the 103 sampled areas in the suicide group (n = 18 pairs; P < 0.0001). The increase ranged from 17 to 30%. The increase was more pronounced in the ventrolateral prefrontal cortex. Serotonin transporter binding was found to be lower in the suicide group in all but one of the 43 sampled regions (n = 22 pairs; P < 0.0001). The reduction in binding was most pronounced in the ventrolateral prefrontal cortex, where the difference between suicides and controls ranged between 15 and 27%. Serotonin transporter and 5-HT1A binding were negatively correlated (r = - 0.35 to - 0.44, P = 0.04 to 0.007) within the same brain areas, suggesting common regulatory factors with opposite effects on binding to the two receptors. We conclude that suicide victims have an abnormality in the serotonin system involving predominantly the ventrolateral prefrontal cortex, and hypothesize that the serotonergic dysfunction in this brain region contributes to the risk for suicidal behavior.